MULTISPECIES: substrate-binding domain-containing protein

LOCUS       WP_002882866             331 aa            linear   BCT 02-MAR-2025
            [Klebsiella].
ACCESSION   WP_002882866
VERSION     WP_002882866.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
REFERENCE   1  (residues 1 to 331)
  AUTHORS   Swint-Kruse,L. and Matthews,K.S.
  TITLE     Allostery in the LacI/GalR family: variations on a theme
  JOURNAL   Curr Opin Microbiol 12 (2), 129-137 (2009)
   PUBMED   19269243
REFERENCE   2  (residues 1 to 331)
  AUTHORS   Fukami-Kobayashi,K., Tateno,Y. and Nishikawa,K.
  TITLE     Parallel evolution of ligand specificity between LacI/GalR family
            repressors and periplasmic sugar-binding proteins
  JOURNAL   Mol Biol Evol 20 (2), 267-277 (2003)
   PUBMED   12598694
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF024770.6
            Evidence Source    :: EMBL-EBI
            Source Identifier  :: PF13377.12
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     Protein         1..331
                     /product="substrate-binding domain-containing protein"
                     /calculated_mol_wt=36435
     Region          1..66
                     /region_name="HTH_LACI"
                     /note="helix_turn _helix lactose operon repressor;
                     smart00354"
                     /db_xref="CDD:197675"
     Site            order(4,12..16,18..19,22,27..28,31,44,47,50..51,53..54)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143331"
     Site            44..53
                     /site_type="active"
                     /note="domain linker motif [active]"
                     /db_xref="CDD:143331"
     Region          60..326
                     /region_name="PBP1_AglR-like"
                     /note="Ligand-binding domain of DNA transcription
                     repressor specific for alpha-glucosides (AglR) and similar
                     proteins; cd20010"
                     /db_xref="CDD:380665"
     Site            order(65,78..79,81..83,86,94..97,99,117,222,225,247,254)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:380665"
     Site            order(76,80,145..146,157..160,196,245,274)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:380665"
ORIGIN      
        1 mslkaiakql gisvttvsra lngyddvsqe trarveaeaq rrgyrpntfa rrlkmgtida
       61 vglvfpvrpa plnnnvflem vgeishelar hdidllliad deqadkhgym rmvqgrrvda
      121 livahtlddd prlaqlqasg fpflalgrsr laqpyawfdf dnyagtcrat rhliqqghqr
      181 iallgennnq afilqrrngy ldalreagls dawlrsvpat rrggyqatle llrlpeppta
      241 iitdcnthgd gaamalahlg rltgdnrval vvydglpqds iietdvaavi qstrqgvgrq
      301 iadmvrrlia gedlatlqvl wqpefipget a