MULTISPECIES: mandelate racemase/muconate lactonizing enzyme family

LOCUS       WP_001687378             397 aa            linear   BCT 22-JUL-2024
            protein [Salmonella].
ACCESSION   WP_001687378
VERSION     WP_001687378.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 397)
  AUTHORS   Gerlt,J.A., Babbitt,P.C. and Rayment,I.
  TITLE     Divergent evolution in the enolase superfamily: the interplay of
            mechanism and specificity
  JOURNAL   Arch Biochem Biophys 433 (1), 59-70 (2005)
   PUBMED   15581566
REFERENCE   2  (residues 1 to 397)
  AUTHORS   Babbitt,P.C., Hasson,M.S., Wedekind,J.E., Palmer,D.R.,
            Barrett,W.C., Reed,G.H., Rayment,I., Ringe,D., Kenyon,G.L. and
            Gerlt,J.A.
  TITLE     The enolase superfamily: a general strategy for enzyme-catalyzed
            abstraction of the alpha-protons of carboxylic acids
  JOURNAL   Biochemistry 35 (51), 16489-16501 (1996)
   PUBMED   8987982
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10129511
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     Protein         1..397
                     /product="mandelate racemase/muconate lactonizing enzyme
                     family protein"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /calculated_mol_wt=43527
     Region          3..382
                     /region_name="MR_like"
                     /note="Mandelate racemase (MR)-like subfamily of the
                     enolase superfamily. Enzymes of this subgroup share three
                     conserved carboxylate ligands for the essential divalent
                     metal ion (usually Mg2+), two aspartates and a glutamate,
                     and conserved catalytic residues; cd03316"
                     /db_xref="CDD:239432"
     Site            order(170,172,219,245,271,294,321,346)
                     /site_type="active"
                     /note="active site pocket [active]"
                     /db_xref="CDD:239432"
ORIGIN      
        1 mmkitsvdii dvandfasat skwrpvvvki ntdegisgfg evglaygvga sagigmakdl
       61 saiiigmdpm nneaiwekml kktfwgqggg gifsaamsgi dialwdikgk awgvplykml
      121 ggksrekirt yasqlqfgwg dgsdkdmlte peqyaqaalt avsegydaik vdtvamdrhg
      181 nwnqqnlngp ltdkilrlgy drmaairdav gpdvdiiaem haftdttsai qfgrmieelg
      241 ifyyeepvmp lnpaqmkqva dkvniplaag eriywrwgyr pflengslsv iqpdictcgg
      301 itevkkicdm ahvydktvqi hvcggpista valhmetaip nfvihelhry allepntqtc
      361 kynylpkngm yevpelpgig qelteetmkk sptitvk