MFS transporter [Salmonella enterica].

LOCUS       WP_001616383             449 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_001616383
VERSION     WP_001616383.1
KEYWORDS    RefSeq.
SOURCE      Salmonella enterica
  ORGANISM  Salmonella enterica
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Salmonella.
REFERENCE   1  (residues 1 to 449)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 449)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 449)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13024624
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Salmonella enterica"
                     /db_xref="taxon:28901"
     Protein         1..449
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=47874
     Region          12..384
                     /region_name="MFS_YajR_like"
                     /note="Escherichia coli inner membrane transport protein
                     YajR and similar multidrug-efflux transporters of the
                     Major Facilitator Superfamily; cd17472"
                     /db_xref="CDD:341025"
     Site            order(19..20,23..24,27,60,110..111,113..115,118,140,
                     143..144,147,216,219..220,223..225,228,255,259,303..304,
                     308,312,335,338..339,342..343,346)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:341025"
ORIGIN      
        1 mtpgelratw glgtvfslrm lgmfmvlpvl ttygmalqga sealigiaig iyglaqaifq
       61 ipfgllsdri grkplivggl avfvagsvia alshsiwgii lgralqgsga iaaavmalls
      121 dltreqnrtk amafigvsfg itfaiamvlg pivthslgln alfwmiaala tlgilltiwv
      181 vpnstnhvln resgmvkgsf skvlaeprll klnfgimclh illmstfval pgqladagfp
      241 aaehwkvyla tmviafaavv pfiiyaevkr rmkqvflfcv glivvaeivl wgagqhfwel
      301 vigvqlffla fnlmeallps liskespagy kgtamgvyst sqflgvalgg slggwidgtf
      361 dgqtvflaga vlamvwlava stmkeppyvs slrveipadi vaddrlkqrl lamkgvseal
      421 ivaeehsayv kidskvtnrf eveqliskg