bifunctional phosphopantothenoylcysteine

LOCUS       WP_001541625             407 aa            linear   BCT 17-JUN-2024
            decarboxylase/phosphopantothenate--cysteine ligase CoaBC
            [Salmonella enterica].
ACCESSION   WP_001541625
VERSION     WP_001541625.1
KEYWORDS    RefSeq.
SOURCE      Salmonella enterica
  ORGANISM  Salmonella enterica
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Salmonella.
REFERENCE   1  (residues 1 to 407)
  AUTHORS   Strauss,E., Kinsland,C., Ge,Y., McLafferty,F.W. and Begley,T.P.
  TITLE     Phosphopantothenoylcysteine synthetase from Escherichia coli.
            Identification and characterization of the last unidentified
            coenzyme A biosynthetic enzyme in bacteria
  JOURNAL   J Biol Chem 276 (17), 13513-13516 (2001)
   PUBMED   11278255
REFERENCE   2  (residues 1 to 407)
  AUTHORS   Spitzer,E.D., Jimenez-Billini,H.E. and Weiss,B.
  TITLE     beta-Alanine auxotrophy associated with dfp, a locus affecting DNA
            synthesis in Escherichia coli
  JOURNAL   J Bacteriol 170 (2), 872-876 (1988)
   PUBMED   3123465
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00521.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..407
                     /organism="Salmonella enterica"
                     /db_xref="taxon:28901"
     gene            1..407
                     /gene="coaBC"
     Protein         1..407
                     /product="bifunctional phosphopantothenoylcysteine
                     decarboxylase/phosphopantothenate--cysteine ligase CoaBC"
                     /EC_number="4.1.1.36"
                     /EC_number="6.3.2.5"
                     /GO_function="GO:0004632 - phosphopantothenate--cysteine
                     ligase activity [Evidence IEA]"
                     /GO_function="GO:0004633 - phosphopantothenoylcysteine
                     decarboxylase activity [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_process="GO:0015937 - coenzyme A biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0015941 - pantothenate catabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=43423
     Region          1..403
                     /region_name="PRK05579"
                     /note="bifunctional phosphopantothenoylcysteine
                     decarboxylase/phosphopantothenate synthase; Validated"
                     /db_xref="CDD:235513"
ORIGIN      
        1 mmslagkkiv lgvsggiaay ktpelvrrlr ehgadvrvam teaakafitp lslqavsgyp
       61 vsdslldpaa eaamghielg kwadlvilap atadliarva sgmandlvst iclatpapva
      121 vlpamnqqmy raaatqhnle vlasrglfiw gpdsgsqacg dvgpgrmldp lvivdkaaah
      181 faavndlrhl nimitagptr epldpvryis nhssgkmgfa iaaaaarrga nvtlvsgpvs
      241 lptppfvkrv dvitaldmea avqaavqqqh ifiscaavad yraetiasek ikkqaaqgde
      301 llikmvknpd ivagvaalsd nrpyvvgfaa etnnveeyar qkrirknldl icandvslsn
      361 qgfnsdknal hlfwqdgdkv lplerkellg qllldeivtr ydeknrr