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LOCUS WP_001393448 353 aa linear BCT 24-DEC-2024 coli]. ACCESSION WP_001393448 VERSION WP_001393448.1 KEYWORDS RefSeq. SOURCE Escherichia coli ORGANISM Escherichia coli Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. REFERENCE 1 (residues 1 to 353) AUTHORS Persson,B., Hedlund,J. and Jornvall,H. TITLE Medium- and short-chain dehydrogenase/reductase gene and protein families : the MDR superfamily JOURNAL Cell Mol Life Sci 65 (24), 3879-3894 (2008) PUBMED 19011751 REFERENCE 2 (residues 1 to 353) AUTHORS Auld,D.S. and Bergman,T. TITLE Medium- and short-chain dehydrogenase/reductase gene and protein families : The role of zinc for alcohol dehydrogenase structure and function JOURNAL Cell Mol Life Sci 65 (24), 3961-3970 (2008) PUBMED 19011745 REFERENCE 3 (residues 1 to 353) AUTHORS Gonzalez-Duarte,R. and Albalat,R. TITLE Merging protein, gene and genomic data: the evolution of the MDR-ADH family JOURNAL Heredity (Edinb) 95 (3), 184-197 (2005) PUBMED 16121213 REFERENCE 4 (residues 1 to 353) AUTHORS Nordling,E., Jornvall,H. and Persson,B. TITLE Medium-chain dehydrogenases/reductases (MDR). Family characterizations including genome comparisons and active site modeling JOURNAL Eur J Biochem 269 (17), 4267-4276 (2002) PUBMED 12199705 REFERENCE 5 (residues 1 to 353) AUTHORS Lesk,A.M. TITLE NAD-binding domains of dehydrogenases JOURNAL Curr Opin Struct Biol 5 (6), 775-783 (1995) PUBMED 8749365 REFERENCE 6 (residues 1 to 353) AUTHORS Persson,B., Zigler,J.S. Jr. and Jornvall,H. TITLE A super-family of medium-chain dehydrogenases/reductases (MDR). Sub-lines including zeta-crystallin, alcohol and polyol dehydrogenases, quinone oxidoreductase enoyl reductases, VAT-1 and other proteins JOURNAL Eur J Biochem 226 (1), 15-22 (1994) PUBMED 7957243 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 10169520 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..353 /organism="Escherichia coli" /db_xref="taxon:562" Protein 1..353 /product="zinc-dependent alcohol dehydrogenase family protein" /EC_number="1.-.-.-" /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]" /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /GO_function="GO:0030554 - adenyl nucleotide binding [Evidence IEA]" /calculated_mol_wt=37920 Region 4..351 /region_name="THR_DH_like" /note="L-threonine dehydrogenase (TDH)-like; cd08239" /db_xref="CDD:176201" Site order(40..42,45,158,162,182..187,206..207,211,227, 250..251,253,273..274,297..299) /site_type="other" /note="putative NAD(P) binding site [chemical binding]" /db_xref="CDD:176201" Site order(40,42,70,158) /site_type="other" /note="catalytic Zn binding site [ion binding]" /db_xref="CDD:176201" ORIGIN 1 mktmlaaylp gnstvdlrev avptpginqv likmkssgic gsdvhyiyhq hrataaapdk 61 plyqgfingh epcgqivamg qgcrhfkegd rvlvyhisgc gfcpncrrgf pisctgegka 121 aygwqrdggh aeyllaeekd lillpdalsy edgafiscgv gtayegilrg evsgsdnvlv 181 vglgpvgmma mmlakgrgak riigvdmlpe rlamakqlgv mdhgylatte glpqiiaelt 241 hggadvaldc sgnaagrlla lqstadwgrv vyigetgkve fevsadlmhh qrriigswvt 301 slfhmekcah dltdwklwpr naithrfsle qagdayalma sgkcgkvvin fpd