MULTISPECIES: type II toxin-antitoxin system RelE/ParE family toxin

LOCUS       WP_001303876              95 aa            linear   BCT 01-JAN-2025
            [Escherichia].
ACCESSION   WP_001303876
VERSION     WP_001303876.1
KEYWORDS    RefSeq.
SOURCE      Escherichia
  ORGANISM  Escherichia
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 95)
  AUTHORS   Hall,A.M., Gollan,B. and Helaine,S.
  TITLE     Toxin-antitoxin systems: reversible toxicity
  JOURNAL   Curr Opin Microbiol 36, 102-110 (2017)
   PUBMED   28279904
REFERENCE   2  (residues 1 to 95)
  AUTHORS   Fiebig,A., Castro Rojas,C.M., Siegal-Gaskins,D. and Crosson,S.
  TITLE     Interaction specificity, toxicity and regulation of a paralogous
            set of ParE/RelE-family toxin-antitoxin systems
  JOURNAL   Mol Microbiol 77 (1), 236-251 (2010)
   PUBMED   20487277
REFERENCE   3  (residues 1 to 95)
  AUTHORS   Dalton,K.M. and Crosson,S.
  TITLE     A conserved mode of protein recognition and binding in a ParD-ParE
            toxin-antitoxin complex
  JOURNAL   Biochemistry 49 (10), 2205-2215 (2010)
   PUBMED   20143871
REFERENCE   4  (residues 1 to 95)
  AUTHORS   Pandey,D.P. and Gerdes,K.
  TITLE     Toxin-antitoxin loci are highly abundant in free-living but lost
            from host-associated prokaryotes
  JOURNAL   Nucleic Acids Res 33 (3), 966-976 (2005)
   PUBMED   15718296
  REMARK    Publication Status: Online-Only
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10007814
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..95
                     /organism="Escherichia"
                     /db_xref="taxon:561"
     Protein         1..95
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /GO_component="GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA]"
                     /GO_function="GO:0090729 - toxin activity [Evidence IEA]"
                     /calculated_mol_wt=10848
     Region          4..92
                     /region_name="ParE"
                     /note="Plasmid stabilization system protein ParE
                     [Mobilome: prophages, transposons]; COG3668"
                     /db_xref="CDD:442885"
ORIGIN      
        1 mlpilwlpsa rddlrqiity iakenppaar rlkirietsv lplsehpyly ppservsglr
       61 eivthpnyii lyrvaassie ivsvthsrrq fpfsi