MFS transporter [Escherichia coli].

LOCUS       WP_001302821             421 aa            linear   BCT 28-MAR-2023
ACCESSION   WP_001302821
VERSION     WP_001302821.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 421)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 421)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
REFERENCE   3  (residues 1 to 421)
  AUTHORS   Yan,N.
  TITLE     Structural advances for the major facilitator superfamily (MFS)
            transporters
  JOURNAL   Trends Biochem Sci 38 (3), 151-159 (2013)
   PUBMED   23403214
REFERENCE   4  (residues 1 to 421)
  AUTHORS   Law,C.J., Maloney,P.C. and Wang,D.N.
  TITLE     Ins and outs of major facilitator superfamily antiporters
  JOURNAL   Annu Rev Microbiol 62, 289-305 (2008)
   PUBMED   18537473
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13024447
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     Protein         1..421
                     /product="MFS transporter"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=45902
     Region          14..394
                     /region_name="MFS_YdiM_like"
                     /note="Inner membrane transport protein YdiM and similar
                     proteins of the Major Facilitator Superfamily of
                     transporters; cd17396"
                     /db_xref="CDD:340954"
     Site            order(25..26,29..30,33,65,115..116,118..120,123,142,
                     145..146,149,219,222..223,226..228,231,262,266,317..318,
                     322,326,342,345..346,349..350,353)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340954"
ORIGIN      
        1 msqnkafstp filavlciyf syflhgisvi tlaqnmssla ekfstdnagi aylisgiglg
       61 rlisilffgv isdkfgrrav ilmavimyll fffgipacpn ltlayglavc vgiansaldt
      121 ggypalmecf pkasgsavil vkamvsfgqm fypmlvsyml lnniwygygl iipgilfvli
      181 tlmllkskfp sqlvdasvan elpqmnskpl vwlegvssvl fgvaafstfy vivvwmpkya
      241 mafagmseae alktisyysm gslvcvfifa allkkmvrpi wanvfnsala titaaiiyly
      301 psplvcnaga fvigfsaagg ilqlgvsvms effpkskakv tsiymmmggl anfviplitg
      361 ylsniglqyi ivldftfall alitaiivfi ryyrvfiipk ndvrfgerkf strlntikhr
      421 g