type I restriction-modification system subunit M [Escherichia

LOCUS       WP_001302468             489 aa            linear   BCT 19-FEB-2025
            coli].
ACCESSION   WP_001302468
VERSION     WP_001302468.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 489)
  AUTHORS   Liu,Y.P., Tang,Q., Zhang,J.Z., Tian,L.F., Gao,P. and Yan,X.X.
  TITLE     Structural basis underlying complex assembly and conformational
            transition of the type I R-M system
  JOURNAL   Proc Natl Acad Sci U S A 114 (42), 11151-11156 (2017)
   PUBMED   28973912
REFERENCE   2  (residues 1 to 489)
  AUTHORS   Sistla,S. and Rao,D.N.
  TITLE     S-Adenosyl-L-methionine-dependent restriction enzymes
  JOURNAL   Crit Rev Biochem Mol Biol 39 (1), 1-19 (2004)
   PUBMED   15121719
REFERENCE   3  (residues 1 to 489)
  AUTHORS   Schubert,H.L., Blumenthal,R.M. and Cheng,X.
  TITLE     Many paths to methyltransfer: a chronicle of convergence
  JOURNAL   Trends Biochem Sci 28 (6), 329-335 (2003)
   PUBMED   12826405
REFERENCE   4  (residues 1 to 489)
  AUTHORS   Williams,R.J.
  TITLE     Restriction endonucleases: classification, properties, and
            applications
  JOURNAL   Mol Biotechnol 23 (3), 225-243 (2003)
   PUBMED   12665693
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13779125
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     Protein         1..489
                     /product="type I restriction-modification system subunit
                     M"
                     /EC_number="2.1.1.-"
                     /EC_number="2.1.1.72"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0009007 - site-specific
                     DNA-methyltransferase (adenine-specific) activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /calculated_mol_wt=55025
     Region          3..130
                     /region_name="HsdM_N"
                     /note="HsdM N-terminal domain; pfam12161"
                     /db_xref="CDD:463478"
     Region          141..452
                     /region_name="N6_Mtase"
                     /note="N-6 DNA Methylase; pfam02384"
                     /db_xref="CDD:426749"
ORIGIN      
        1 msissviksl qdimrkdagv dgdaqrlgql swllflkifd aqeealeleq dnyqypipqr
       61 ylwrswaana qgitgdslle fvnddlfpal knltapidkn prgyvvkqaf sdaynymkng
      121 tllrqvinkl neidftsase rhlfgdiyeq ilkdlqsagn agefytprav trfmvdrvdp
      181 klgesimdpa cgtggflaca fdhvknkyvk svadhqtlqq qihgvekkql phllattnml
      241 lhgievpvqi rhdntlnkpl ssrdeqldvi vtnppfggte edgieknfpa emqtretadl
      301 flqlivevla kngraavvlp dgtlfgegvk tkikklltee cnlhtivrlp ngvfnpytgi
      361 ktnllfftkg qptkeiwfye hpypagvkny sktkpmkfee fqaeidwwgn eadgfasrve
      421 neqawkvsid dviarnfnld iknphqaetv shdpaellaq yakqqaeiqt lrnqlrdilg
      481 aalsgkevn