bifunctional indole-3-glycerol-phosphate synthase

LOCUS       WP_001302292             452 aa            linear   BCT 11-DEC-2019
            TrpC/phosphoribosylanthranilate isomerase TrpF [Escherichia coli].
ACCESSION   WP_001302292
VERSION     WP_001302292.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 452)
  AUTHORS   Eberhard,M. and Kirschner,K.
  TITLE     Modification of a catalytically important residue of
            indoleglycerol-phosphate synthase from Escherichia coli
  JOURNAL   FEBS Lett. 245 (1-2), 219-222 (1989)
   PUBMED   2494074
REFERENCE   2  (residues 1 to 452)
  AUTHORS   Priestle,J.P., Grutter,M.G., White,J.L., Vincent,M.G., Kania,M.,
            Wilson,E., Jardetzky,T.S., Kirschner,K. and Jansonius,J.N.
  TITLE     Three-dimensional structure of the bifunctional enzyme
            N-(5'-phosphoribosyl)anthranilate
            isomerase-indole-3-glycerol-phosphate synthase from Escherichia
            coli
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 84 (16), 5690-5694 (1987)
   PUBMED   3303031
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF006945.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK09427
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..452
                     /gene="trpCF"
     Protein         1..452
                     /product="bifunctional indole-3-glycerol-phosphate
                     synthase TrpC/phosphoribosylanthranilate isomerase TrpF"
                     /EC_number="4.1.1.48"
                     /EC_number="5.3.1.24"
                     /GO_function="GO:0004425 - indole-3-glycerol-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0004640 - phosphoribosylanthranilate
                     isomerase activity [Evidence IEA]"
                     /GO_process="GO:0006568 - tryptophan metabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=49171
     Region          1..452
                     /region_name="PRK09427"
                     /note="bifunctional indole-3-glycerol-phosphate synthase
                     TrpC/phosphoribosylanthranilate isomerase TrpF"
                     /db_xref="CDD:236509"
ORIGIN      
        1 mqtvlakiva dkaiwveark qqqplasfqn evqpstrhfy dalqgartaf ileckkasps
       61 kgvicddfdp ariaaiykhy asaisvltde kyfqgsfdfl pivsqiapqp ilckdfiidp
      121 yqiylaryyq adacllmlsv lddeqyrqla avahslkmgv ltevsneeel eraialgakv
      181 vginnrdlrd lsidlnrtre lapklghnvt visesginty aqvrelshfa dgfligsalm
      241 ahddlhaavr rvllgenkvc gltrgqdaka aydagaiygg lifvatsprc vnveqaqevm
      301 aaaplqyvgv frnhdiadvl dkakvlslva vqlhgnedql yidtlrealp ahvaiwkals
      361 vgetlparel qhvdkyvldn gqggsgqrfd wsllngqslg nvllagglga dncveaaqtg
      421 cagldfnsav esqpgikdar llasvfqtlr ay