voltage-gated ClC-type chloride channel ClcB [Escherichia coli].

LOCUS       WP_001302066             418 aa            linear   BCT 20-JUN-2019
ACCESSION   WP_001302066
VERSION     WP_001302066.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF002437.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK01610
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..418
                     /gene="clcB"
     Protein         1..418
                     /product="voltage-gated ClC-type chloride channel ClcB"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005247 - voltage-gated chloride channel
                     activity [Evidence IEA]"
                     /GO_process="GO:0006821 - chloride transport [Evidence
                     IEA]"
                     /GO_process="GO:0010447 - response to acidic pH [Evidence
                     IEA]"
                     /calculated_mol_wt=44014
     Region          1..418
                     /region_name="PRK01610"
                     /note="putative voltage-gated ClC-type chloride channel
                     ClcB; Provisional"
                     /db_xref="CDD:234963"
     Site            order(84..88,118..122,320..324)
                     /site_type="active"
                     /note="Cl- selectivity filter [active]"
                     /db_xref="CDD:238233"
     Site            order(85,87,120..121,320..322)
                     /site_type="other"
                     /note="Cl- binding residues [ion binding]"
                     /db_xref="CDD:238233"
     Site            120
                     /site_type="active"
                     /note="pore gating glutamate residue [active]"
                     /db_xref="CDD:238233"
     Site            order(164,173,188,195,368,371,379,387,394..395)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238233"
ORIGIN      
        1 mfrrlliatv vgilaafava gfrhamllle wlflnndsgs lvnaatnlsp wrrlltpalg
       61 glaaglllmg wqkftqqrph aptdymealq tdgqfdyaas lvkslasllv vtsgsaigre
      121 gamillaala ascfaqrftp rqewklwiac gaaagmaaay raplagslfi aevlfgtmml
      181 aslgpviisa vvallvsnli nhsdallysv qlsvtvqard yaliistgvl aglcgplllt
      241 lmnachrgfv slklappwql algglivgll slftpavwgn gystvqsflt appllmiiag
      301 iflcklcavl assgsgapgg vftptlfigl aigmlygrsl glwfpdgeei tlllgltgma
      361 tllaatthap imstlmicem tgeyqllpgl liacviasvi srtlhrdsiy rqhtaqhs