histidinol dehydrogenase [Escherichia coli].

LOCUS       WP_001302028             434 aa            linear   BCT 17-JUN-2024
ACCESSION   WP_001302028
VERSION     WP_001302028.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00069.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..434
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..434
                     /gene="hisD"
     Protein         1..434
                     /product="histidinol dehydrogenase"
                     /EC_number="1.1.1.23"
                     /GO_function="GO:0004399 - histidinol dehydrogenase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=45943
     Region          5..427
                     /region_name="hisD"
                     /note="bifunctional histidinal dehydrogenase/ histidinol
                     dehydrogenase; Reviewed; PRK00877"
                     /db_xref="CDD:234853"
     Site            order(58,130,132..133,141,162,185..186,188,209..211,
                     213..214,262)
                     /site_type="other"
                     /note="NAD binding site [chemical binding]"
                     /db_xref="CDD:119329"
     Site            order(83..84,87..88,90,93..94,97..98,101..102,109,111,
                     115..119,122,124,136..140,204,219,223,250..251,254..255,
                     257..259,261..262,331,336,339..340,342..350,352,354..355,
                     357..361,363,365,375..376,378..382,384..385,388..395,
                     410..411,413..419)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:119329"
     Site            order(138,140,237,262,326..327,356,360..361,367,414,416,
                     419)
                     /site_type="active"
                     /note="product binding site [active]"
                     /db_xref="CDD:119329"
     Site            order(140,237,259,262,326..327,356,360..361,367,414,416,
                     419)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:119329"
     Site            order(259,262,360,419)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:119329"
     Site            326..327
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:119329"
ORIGIN      
        1 msfntiidwn sctakqqrql lmrpaisase sitrtvndil dsvkargdda lreysakfdk
       61 ttvtalkvsa eeiaaaserl sdelkqamav avknietfht aqklppvdve tqpgvrcqqv
      121 trpvasvgly ipggsaplfs tvlmlatpar iagckkvvlc spppiadeil yaaqlcgvqd
      181 vfnvggaqai aalafgtesv pkvdkifgpg nafvteakrq vsqrldgaai dmpagpsevl
      241 viadsgatpd fvasdllsqa ehgpdsqvil ltpdadmahq vaeaverqla elpraetarq
      301 alnasrlivt kdlaqcveis nqygpehlii qtrnarelvd gitsagsvfl gdwspesagd
      361 yasgtnhvlp tygytatcss lgladfqkrm tvqelskvgf salastietl aaaerltahk
      421 navtlrvnal keqa