type 3 dihydrofolate reductase [Escherichia coli].

LOCUS       WP_001301983             196 aa            linear   BCT 09-DEC-2022
ACCESSION   WP_001301983
VERSION     WP_001301983.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF008037.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK10769
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..196
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..196
                     /gene="folA"
     Protein         1..196
                     /product="type 3 dihydrofolate reductase"
                     /GO_function="GO:0004146 - dihydrofolate reductase
                     activity [Evidence IEA]"
                     /GO_process="GO:0046654 - tetrahydrofolate biosynthetic
                     process [Evidence IEA]"
                     /calculated_mol_wt=22139
     Region          38..196
                     /region_name="folA"
                     /note="type 3 dihydrofolate reductase; PRK10769"
                     /db_xref="CDD:182714"
     Site            order(42,59,64,94,131,137,150)
                     /site_type="other"
                     /note="folate binding site [chemical binding]"
                     /db_xref="CDD:238127"
     Site            order(44,51,81..83,101,132..135)
                     /site_type="other"
                     /note="NADP+ binding site [chemical binding]"
                     /db_xref="CDD:238127"
ORIGIN      
        1 mdspaeykif lniilapvdd glrftysgdn ffyreismis liaalavdrv igmenampwn
       61 lpadlawfkr ntlnkpvimg rhtresigrp lpgrkniils sqpgtddrvt wvksvdeaia
      121 acgdvpeimv igggrvyeqf lpkaqklylt hidaevegdt hfpdyepddw esvfsefhda
      181 daqnshsycf eilerr