2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid

LOCUS       WP_001301869             556 aa            linear   BCT 04-JUN-2024
            synthase [Escherichia coli].
ACCESSION   WP_001301869
VERSION     WP_001301869.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 556)
  AUTHORS   Jiang,M., Cao,Y., Guo,Z.F., Chen,M., Chen,X. and Guo,Z.
  TITLE     Menaquinone biosynthesis in Escherichia coli: identification of
            2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate as a
            novel intermediate and re-evaluation of MenD activity
  JOURNAL   Biochemistry 46 (38), 10979-10989 (2007)
   PUBMED   17760421
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00173.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..556
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..556
                     /gene="menD"
     Protein         1..556
                     /product="2-succinyl-5-enolpyruvyl-6-hydroxy-3-
                     cyclohexene-1-carboxylic-acid synthase"
                     /EC_number="2.2.1.9"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0070204 -
                     2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-
                     carboxylic-acid synthase activity [Evidence IEA]"
                     /GO_process="GO:0009234 - menaquinone biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=61161
     Region          2..556
                     /region_name="MenD"
                     /note="2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-
                     carboxylate synthase [Coenzyme transport and metabolism];
                     COG1165"
                     /db_xref="CDD:440779"
ORIGIN      
        1 msvsafnrrw aavilealtr hgvrhiciap gsrstpltla aaensafihh thfderglgh
       61 lalglakvsk qpvavivtsg tavanlypal ieagltgekl illtadrppe lidcganqai
      121 rqpgmfashp thsislprpt qdiparwlvs tidhalgtlh aggvhincpf aeplygemdd
      181 tglswqqrlg dwwqddkpwl reaprlesek qrdwffwrqk rgvvvagrms aeegkkvalw
      241 aqtlgwplig dvlsqtgqpl pcadlwlgna katselqqaq ivvqlgsslt gkrllqwqas
      301 cepeeywivd diegrldpah hrgrrliani adwlelhpae krqpwcveip rlaeqamqav
      361 iacrdafgea qlahrisdyl peqgqlfvgn slvvrlidal sqlpagypvy snrgasgidg
      421 llstaagvqr asgkptlaiv gdlsalydln alallrqvsa plvlivvnnn ggqifsllpt
      481 pksererfyl mpqnvhfeha aamfelkyhr pqnwqeletv ladawrtptt tviemvvndt
      541 dgaqtlqqll aqvshl