aldo/keto reductase [Escherichia coli].

FASTA View on NCBI
LOCUS       WP_001301722             289 aa            linear   BCT 25-JUL-2024
ACCESSION   WP_001301722
VERSION     WP_001301722.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 289)
  AUTHORS   Hyndman,D., Bauman,D.R., Heredia,V.V. and Penning,T.M.
  TITLE     The aldo-keto reductase superfamily homepage
  JOURNAL   Chem Biol Interact 143-144, 621-631 (2003)
   PUBMED   12604248
REFERENCE   2  (residues 1 to 289)
  AUTHORS   Jez,J.M., Bennett,M.J., Schlegel,B.P., Lewis,M. and Penning,T.M.
  TITLE     Comparative anatomy of the aldo-keto reductase superfamily
  JOURNAL   Biochem J 326 (Pt 3) (Pt 3), 625-636 (1997)
   PUBMED   9307009
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 14442695
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     Protein         1..289
                     /product="aldo/keto reductase"
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /calculated_mol_wt=32572
     Region          6..263
                     /region_name="AKR_AKR5F1"
                     /note="the AKR5F family of aldo-keto reductase (AKR);
                     cd19133"
                     /db_xref="CDD:381359"
     Site            order(18..20,44,48..49,78,112..113,140..141,162,188..194,
                     204,216,231..236,239,242..243)
                     /site_type="active"
                     /db_xref="CDD:381359"
     Site            order(44,49,78,112)
                     /site_type="active"
                     /note="catalytic tetrad [active]"
                     /db_xref="CDD:381359"
ORIGIN      
        1 mefsvlsnnl kmpmmgfgvf qvtdknvckq svlnairtgy rlidtaavyg nedavgeavr
       61 eaiseglctr eelfitsklw vqdmlnqdta aagieaslkk sgleyfdlyl lhqamrdyfs
      121 awraledaye egklkaigvs nfyphvlanf cetvrvkpmv nqvelhpyfa qpealatmky
      181 ynvqpeawap lgggrhkpfe nnllqsiada hqksisqvil rwniqrgvvv ipksthqqri
      241 eenfaiwdfs ltekemaqis sldlgyvges vkhfnpefvr gclavkihd