cystathionine gamma-synthase [Escherichia coli].

LOCUS       WP_001301705             386 aa            linear   BCT 20-JUN-2019
ACCESSION   WP_001301705
VERSION     WP_001301705.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF005961.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK08045
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..386
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..386
                     /gene="metB"
     Protein         1..386
                     /product="cystathionine gamma-synthase"
                     /EC_number="2.5.1.48"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0019346 - transsulfuration [Evidence IEA]"
                     /calculated_mol_wt=41405
     Region          1..386
                     /region_name="PRK08045"
                     /note="cystathionine gamma-synthase; Provisional"
                     /db_xref="CDD:169194"
     Site            order(29..32,34..35,46,48,74..75,77..78,101,106,109,197,
                     205,207,224,234,236..237,316)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:99738"
     Site            order(75..77,101,144,173,195,197..198,207)
                     /site_type="active"
                     /note="substrate-cofactor binding pocket [active]"
                     /db_xref="CDD:99738"
     Site            order(75..77,101,173,176,195,197..198)
                     /site_type="other"
                     /note="pyridoxal 5'-phosphate binding site [chemical
                     binding]"
                     /db_xref="CDD:99738"
     Site            198
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:99738"
ORIGIN      
        1 mtrkqatiav rsglnddeqy gcvvppihls stynftgfne prahdysrrg nptrdvvqra
       61 laeleggaga vltntgmsai hlvttvflkp gdllvaphdc yggsyrlfds lakrgcyrvl
      121 fvdqgdeqal raalaenpkl vlvespsnpl lrvvdiakic hlarevgavs vvdntflspa
      181 lqnplalgad lvlhsctkyl nghsdvvagv viakdpdvvt elawwannig vtggafdsyl
      241 llrglrtlvp rmelaqrnak aivkylqtqp lvkklyhpsl penqgheiaa rqqkgfgaml
      301 sfeldgdeqt lrrflgglsl ftlaeslggv eslishaatm thagmapear aaagisetll
      361 ristgiedge dliadlengf raankg