MULTISPECIES: type III secretion system effector E3 ubiquitin

LOCUS       WP_001301673             782 aa            linear   BCT 26-JUN-2020
            ligase NleL [Escherichia].
ACCESSION   WP_001301673
VERSION     WP_001301673.1
KEYWORDS    RefSeq.
SOURCE      Escherichia
  ORGANISM  Escherichia
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 782)
  AUTHORS   Sheng,X., You,Q., Zhu,H., Chang,Z., Li,Q., Wang,H., Wang,C.,
            Wang,H., Hui,L., Du,C., Xie,X., Zeng,R., Lin,A., Shi,D., Ruan,K.,
            Yan,J., Gao,G.F., Shao,F. and Hu,R.
  TITLE     Bacterial effector NleL promotes enterohemorrhagic E. coli-induced
            attaching and effacing lesions by ubiquitylating and inactivating
            JNK
  JOURNAL   PLoS Pathog. 13 (7), e1006534 (2017)
   PUBMED   28753655
REFERENCE   2  (residues 1 to 782)
  AUTHORS   Lin,D.Y., Diao,J. and Chen,J.
  TITLE     Crystal structures of two bacterial HECT-like E3 ligases in complex
            with a human E2 reveal atomic details of pathogen-host interactions
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 109 (6), 1925-1930 (2012)
   PUBMED   22308380
REFERENCE   3  (residues 1 to 782)
  AUTHORS   Piscatelli,H., Kotkar,S.A., McBee,M.E., Muthupalani,S.,
            Schauer,D.B., Mandrell,R.E., Leong,J.M. and Zhou,D.
  TITLE     The EHEC type III effector NleL is an E3 ubiquitin ligase that
            modulates pedestal formation
  JOURNAL   PLoS ONE 6 (4), e19331 (2011)
   PUBMED   21541301
REFERENCE   4  (residues 1 to 782)
  AUTHORS   Lin,D.Y., Diao,J., Zhou,D. and Chen,J.
  TITLE     Biochemical and structural studies of a HECT-like ubiquitin ligase
            from Escherichia coli O157:H7
  JOURNAL   J. Biol. Chem. 286 (1), 441-449 (2011)
   PUBMED   20980253
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR006076
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..782
                     /organism="Escherichia"
                     /db_xref="taxon:561"
     gene            1..782
                     /gene="nleL"
     Protein         1..782
                     /product="type III secretion system effector E3 ubiquitin
                     ligase NleL"
                     /calculated_mol_wt=87416
     Region          7..782
                     /region_name="PRK15377"
                     /note="type III secretion system effector HECT-type E3
                     ubiquitin transferase"
                     /db_xref="CDD:185275"
ORIGIN      
        1 mlpttnisvn sgvisfespv dspsnedvev alekwcaege fsenrhevas kildvistng
       61 etlsisepit tlpdllpgsl kelvlngcte lksinclppn lsslsmvgcs slevincsip
      121 envinlslch csslkhiegs fpealrnsvy lngcnslnes qcqflaydvs qgraclskae
      181 ltadliwlsa nrtgeesaee lnysgcdlsg lslvglnlss vnfsgavldd tdlrmsdlsq
      241 avlencsfkn silnecnfcy anlsnciira lfensnfsns nlknasfkgs syiqyppiln
      301 eadltgaiii pgmvlsgail gdvkelfsek sntinlggcy idlsdiqeni lsvldnytks
      361 nksilltmnt sddkynhdkv raaeelikki sldelaafrp yvkmsladsf sihpylnnan
      421 iqqwlepicd dffdtimswf nnsimmymen gsllqagmyf erhpgamvsy nssfiqivmn
      481 gsrrdgmqer frelyevylk nekvypvtqq sdfglcdgsg kpdwdddsdl aynwvllssq
      541 ddgmammcsl shmvdmlspn tstnwmsffl ykdgevqntf gyslsnlfse sfpifsipyh
      601 kafsqnfvsg ildilisdne lkerfiealn snksdykmia ddqqrklacv wnpfldgwel
      661 naqhvdmimg shvlkdmplr kqaeilfclg gvfckysssd mfgteydspe ilrryangli
      721 eqayktdpqv fgsvyyyndi ldrlqgrnnv ftctavltdm ltehakesfp eifslyypva
      781 wr