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MULTISPECIES: methionine--tRNA ligase [Enterobacteriaceae].


LOCUS       WP_001301615             677 aa            linear   BCT 20-JUN-2020
ACCESSION   WP_001301615
VERSION     WP_001301615.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 677)
  AUTHORS   Ochsner,U.A., Young,C.L., Stone,K.C., Dean,F.B., Janjic,N. and
            Critchley,I.A.
  TITLE     Mode of action and biochemical characterization of REP8839, a novel
            inhibitor of methionyl-tRNA synthetase
  JOURNAL   Antimicrob. Agents Chemother. 49 (10), 4253-4262 (2005)
   PUBMED   16189106
REFERENCE   2  (residues 1 to 677)
  AUTHORS   Nakanishi,K., Ogiso,Y., Nakama,T., Fukai,S. and Nureki,O.
  TITLE     Structural basis for anticodon recognition by methionyl-tRNA
            synthetase
  JOURNAL   Nat. Struct. Mol. Biol. 12 (10), 931-932 (2005)
   PUBMED   16155581
REFERENCE   3  (residues 1 to 677)
  AUTHORS   Datta,D., Vaidehi,N., Zhang,D. and Goddard,W.A. 3rd.
  TITLE     Selectivity and specificity of substrate binding in methionyl-tRNA
            synthetase
  JOURNAL   Protein Sci. 13 (10), 2693-2705 (2004)
   PUBMED   15388861
REFERENCE   4  (residues 1 to 677)
  AUTHORS   Serre,L., Verdon,G., Choinowski,T., Hervouet,N., Risler,J.L. and
            Zelwer,C.
  TITLE     How methionyl-tRNA synthetase creates its amino acid recognition
            pocket upon L-methionine binding
  JOURNAL   J. Mol. Biol. 306 (4), 863-876 (2001)
   PUBMED   11243794
REFERENCE   5  (residues 1 to 677)
  AUTHORS   Mechulam,Y., Schmitt,E., Maveyraud,L., Zelwer,C., Nureki,O.,
            Yokoyama,S., Konno,M. and Blanquet,S.
  TITLE     Crystal structure of Escherichia coli methionyl-tRNA synthetase
            highlights species-specific features
  JOURNAL   J. Mol. Biol. 294 (5), 1287-1297 (1999)
   PUBMED   10600385
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF001100.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK00133
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..677
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..677
                     /gene="metG"
     Protein         1..677
                     /product="methionine--tRNA ligase"
                     /EC_number="6.1.1.10"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004825 - methionine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006431 - methionyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /calculated_mol_wt=76124
     Region          6..677
                     /region_name="metG"
                     /note="methionyl-tRNA synthetase; Reviewed; PRK00133"
                     /db_xref="CDD:234655"
ORIGIN      
        1 mtqvakkilv tcalpyangs ihlghmlehi qadvwvryqr mrghevnfic addahgtpim
       61 lkaqqlgitp eqmigemsqe hqtdfagfni sydnyhsths eenrqlseli ytrlkengfi
      121 knrtisqlyd pekgmflpdr fvkgtcpkck spdqygdnce vcgatyspte liepksvvsg
      181 atpvmrdseh fffdlpsfse mlqawtrsga lqeqvankmq ewfesglqqw disrdapyfg
      241 feipnapgky fyvwldapig ymgsfknlcd krgdsvsfde ywkkdstael yhfigkdivy
      301 fhslfwpaml egsnfrkptn lfvhgyvtvn gakmsksrgt fikastwlnh fdadslryyy
      361 taklssridd idlnledfvq rvnadivnkv vnlasrnagf inkrfdgvla seladpqlyk
      421 tftdaaevig eawesrefgk avreimalad lanryvdeqa pwvvakqegr dadlqaicsm
      481 ginlfrvlmt ylkpvlpklt eraeaflnte ltwdgiqqpl lghkvnpfka lynridmkqv
      541 ealveaskee vkaaaapvtg pladdpiqet itfddfakvd lrvalienae fvegsdkllr
      601 ltldlggekr nvfsgirsay pdpqaligrh timvanlapr kmrfgisegm vmaagpggkd
      661 ifllspdaga kpghqvk