MULTISPECIES: DNA-binding transcriptional activator/c-di-GMP

LOCUS       WP_001301264             362 aa            linear   BCT 19-JAN-2021
            phosphodiesterase PdeL [Enterobacteriaceae].
ACCESSION   WP_001301264
VERSION     WP_001301264.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 362)
  AUTHORS   Reinders,A., Hee,C.S., Ozaki,S., Mazur,A., Boehm,A., Schirmer,T.
            and Jenal,U.
  TITLE     Expression and Genetic Activation of Cyclic Di-GMP-Specific
            Phosphodiesterases in Escherichia coli
  JOURNAL   J. Bacteriol. 198 (3), 448-462 (2015)
   PUBMED   26553851
REFERENCE   2  (residues 1 to 362)
  AUTHORS   Sundriyal,A., Massa,C., Samoray,D., Zehender,F., Sharpe,T.,
            Jenal,U. and Schirmer,T.
  TITLE     Inherent regulation of EAL domain-catalyzed hydrolysis of second
            messenger cyclic di-GMP
  JOURNAL   J. Biol. Chem. 289 (10), 6978-6990 (2014)
   PUBMED   24451384
REFERENCE   3  (residues 1 to 362)
  AUTHORS   Schmidt,A.J., Ryjenkov,D.A. and Gomelsky,M.
  TITLE     The ubiquitous protein domain EAL is a cyclic diguanylate-specific
            phosphodiesterase: enzymatically active and inactive EAL domains
  JOURNAL   J. Bacteriol. 187 (14), 4774-4781 (2005)
   PUBMED   15995192
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            REFSEQ INFORMATION: The reference sequence is identical to P21514.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR011010
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..362
                     /gene="pdeL"
     Protein         1..362
                     /product="DNA-binding transcriptional activator/c-di-GMP
                     phosphodiesterase PdeL"
                     /EC_number="3.1.4.52"
                     /calculated_mol_wt=40594
     Region          26..80
                     /region_name="LuxR_C_like"
                     /note="C-terminal DNA-binding domain of LuxR-like
                     proteins. This domain contains a helix-turn-helix motif
                     and binds DNA. Proteins belonging to this group are
                     response regulators; some act as transcriptional
                     activators, others as transcriptional repressors. Many...;
                     cd06170"
                     /db_xref="CDD:99777"
     Site            order(26..28,41..43,51..52,54..55,57..61,72)
                     /site_type="DNA binding"
                     /note="DNA binding residues [nucleotide binding]"
                     /db_xref="CDD:99777"
     Site            order(37,39,41,72..74,77,80)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:99777"
     Region          110..350
                     /region_name="EAL"
                     /note="Putative diguanylate phosphodiesterase; smart00052"
                     /db_xref="CDD:214491"
ORIGIN      
        1 mnscdfrvfl qefgttvhls lpgsvseker lllkllmqgm svteisqyrn rsaktishqk
       61 kqlfeklgiq sditfwrdif fqynpeiisa tgsnshryin dnhyhhivtp eaislalenh
      121 efkpwiqpvf caqtgvltgc evlvrwehpq tgiippdqfi plaessgliv imtrqlmkqt
      181 adilmpvkhl lpdnfhigin vsagcflaag fekeclnlvn klgndkiklv lelternpip
      241 vtpearaifd slhqhnitfa lddfgtgyat yrylqafpvd fikidksfvq masvdeisgh
      301 ivdnivelar kpglsivaeg vetqeqadlm igkgvhflqg ylysppvpgn kfisewvmka
      361 gg