MULTISPECIES: 3-isopropylmalate dehydratase large subunit

LOCUS       WP_001274854             473 aa            linear   BCT 01-JUL-2024
            [Salmonella].
ACCESSION   WP_001274854
VERSION     WP_001274854.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00170.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     gene            1..473
                     /gene="leuC"
     Protein         1..473
                     /product="3-isopropylmalate dehydratase large subunit"
                     /EC_number="4.2.1.33"
                     /GO_component="GO:0009316 - 3-isopropylmalate dehydratase
                     complex [Evidence IEA]"
                     /GO_function="GO:0003861 - 3-isopropylmalate dehydratase
                     activity [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster
                     binding [Evidence IEA]"
                     /GO_process="GO:0009098 - L-leucine biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=51315
     Region          1..472
                     /region_name="PRK12466"
                     /note="3-isopropylmalate dehydratase large subunit"
                     /db_xref="CDD:183543"
     Site            order(35,38,131..132,414,433,438)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:153133"
     Site            order(133,350,410,413..414,432)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:153133"
ORIGIN      
        1 msaktlyekl veshtireld neghvllyid rsilneytsp qafsglrerg rtvrhpdtfl
       61 lnidhvnptr sqrddlmtdp ggqlqvdyfr enaadfgitl fdvldprqgi ehvvaheqgl
      121 vmpgmviaag dshtttygaf galgfgigts eiehllatqt lvyrklktmr vsvqgelpfa
      181 csakdivlel lerigadgat gyaiefvgea isalsvegrm tlcnmaveag argaiiapdk
      241 kvfdyiygkp qmpvgelwqq allewsqlss dadavfdktv ainchdlepk vtwgispdqt
      301 gsitgrvpfp eqetnplkrl alekalhymg ltagmllkdi rishafigsc tngriedlra
      361 vakvlegrki ashvrgiivp gstmvrrqae eeglakifia agfewrqsgc smclamnedv
      421 lspgdrcasg tnrnfpgrqg agarthlmsp amvaaaavag hlvdvrsllq age