MULTISPECIES: L-talarate/galactarate dehydratase [Salmonella].

LOCUS       WP_001218249             398 aa            linear   BCT 26-NOV-2024
ACCESSION   WP_001218249
VERSION     WP_001218249.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 398)
  AUTHORS   Easton,N.M., Aboushawareb,S.A.E. and Bearne,S.L.
  TITLE     A continuous assay for l-talarate/galactarate dehydratase using
            circular dichroism
  JOURNAL   Anal Biochem 544, 80-86 (2018)
   PUBMED   29248502
REFERENCE   2  (residues 1 to 398)
  AUTHORS   Yew,W.S., Fedorov,A.A., Fedorov,E.V., Almo,S.C. and Gerlt,J.A.
  TITLE     Evolution of enzymatic activities in the enolase superfamily:
            L-talarate/galactarate dehydratase from Salmonella typhimurium LT2
  JOURNAL   Biochemistry 46 (33), 9564-9577 (2007)
   PUBMED   17649980
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF047820.1
            Evidence Source    :: NCBIFAM
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..398
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     Protein         1..398
                     /product="L-talarate/galactarate dehydratase"
                     /EC_number="4.2.1.156"
                     /EC_number="4.2.1.42"
                     /GO_function="GO:0008867 - galactarate dehydratase
                     activity [Evidence IEA]"
                     /GO_function="GO:1990594 - L-altrarate dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0046392 - galactarate catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:1903663 - L-altrarate catabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=43896
     Region          27..379
                     /region_name="MR_like"
                     /note="Mandelate racemase (MR)-like subfamily of the
                     enolase superfamily. Enzymes of this subgroup share three
                     conserved carboxylate ligands for the essential divalent
                     metal ion (usually Mg2+), two aspartates and a glutamate,
                     and conserved catalytic residues; cd03316"
                     /db_xref="CDD:239432"
     Site            order(195,197,226,252,278,301,328,348)
                     /site_type="active"
                     /note="active site pocket [active]"
                     /db_xref="CDD:239432"
ORIGIN      
        1 malsansdav tyakaantrt aaetgdriew vklslaflpl atpvsdakvl tgrqkpltev
       61 aiiiaeirsr dgfegvgfsy skraggqgiy ahakeiadnl lgedpndidk iytkllwaga
      121 svgrsgmavq aispidialw dmkakraglp lakllgahrd svqcyntsgg flhtpldqvl
      181 knvvisreng iggiklkvgq pncaedirrl tavrealgde fplmvdanqq wdretairmg
      241 rkmeqfnliw ieepldaydi eghaqlaaal dtpiatgeml tsfreheqli lgnasdfvqp
      301 daprvggisp flkimdlaak hgrklaphfa mevhlhlsaa yplepwlehf ewlnplfneq
      361 lelrdgrmwi sdrhglgftl seqarrwtql tcefgkrp