MULTISPECIES: bifunctional indole-3-glycerol-phosphate synthase

LOCUS       WP_001195296             452 aa            linear   BCT 11-DEC-2019
            TrpC/phosphoribosylanthranilate isomerase TrpF [Salmonella].
ACCESSION   WP_001195296
VERSION     WP_001195296.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 452)
  AUTHORS   Eberhard,M. and Kirschner,K.
  TITLE     Modification of a catalytically important residue of
            indoleglycerol-phosphate synthase from Escherichia coli
  JOURNAL   FEBS Lett. 245 (1-2), 219-222 (1989)
   PUBMED   2494074
REFERENCE   2  (residues 1 to 452)
  AUTHORS   Priestle,J.P., Grutter,M.G., White,J.L., Vincent,M.G., Kania,M.,
            Wilson,E., Jardetzky,T.S., Kirschner,K. and Jansonius,J.N.
  TITLE     Three-dimensional structure of the bifunctional enzyme
            N-(5'-phosphoribosyl)anthranilate
            isomerase-indole-3-glycerol-phosphate synthase from Escherichia
            coli
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 84 (16), 5690-5694 (1987)
   PUBMED   3303031
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF006945.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK09427
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     gene            1..452
                     /gene="trpCF"
     Protein         1..452
                     /product="bifunctional indole-3-glycerol-phosphate
                     synthase TrpC/phosphoribosylanthranilate isomerase TrpF"
                     /EC_number="4.1.1.48"
                     /EC_number="5.3.1.24"
                     /GO_function="GO:0004425 - indole-3-glycerol-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0004640 - phosphoribosylanthranilate
                     isomerase activity [Evidence IEA]"
                     /GO_process="GO:0006568 - tryptophan metabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=49071
     Region          1..452
                     /region_name="PRK09427"
                     /note="bifunctional indole-3-glycerol-phosphate synthase
                     TrpC/phosphoribosylanthranilate isomerase TrpF"
                     /db_xref="CDD:236509"
ORIGIN      
        1 mqtvlakiva dkaiwveark qqqplasfqn eiqpstrhfy dalqgartaf ileckkasps
       61 kgvirddfdp ariasiyqhy asaisvltde kyfqgsfdfl pvvsqsapqp ilckdfiidp
      121 yqiylaryyq adacllmlsv lddeqyrqls avahslkmgv ltevsndeer eraialgakv
      181 vginnrdlrd lsidlnrtrq lapklghgvt visesginty gqvrelshfa ngfligsalm
      241 ahddlnaavr rvllgenkvc gltraqdaka acdagaiygg lifvpsspra vsveqarevi
      301 sgaplqyvgv fknadiadvc qkaavlslsa vqlhgsedqa yvnalrealp kqvqiwkals
      361 vsdalpardy hhvdkyifdn gqggsgqrfd wsllqgqpld nvllagglaa dncvqaaqvg
      421 cagldfnsgv esqpgikdar llasvfqtlr ay