MULTISPECIES: bifunctional hydroxymethylpyrimidine

LOCUS       WP_001188957             266 aa            linear   BCT 02-JUN-2019
            kinase/phosphomethylpyrimidine kinase [Salmonella].
ACCESSION   WP_001188957
VERSION     WP_001188957.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 266)
  AUTHORS   Mizote,T., Tsuda,M., Smith,D.D., Nakayama,H. and Nakazawa,T.
  TITLE     Cloning and characterization of the thiD/J gene of Escherichia coli
            encoding a thiamin-synthesizing bifunctional enzyme,
            hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase
  JOURNAL   Microbiology (Reading, Engl.) 145 (Pt 2), 495-501 (1999)
   PUBMED   10075431
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00097.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..266
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     gene            1..266
                     /gene="thiD"
     Protein         1..266
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /EC_number="2.7.1.49"
                     /EC_number="2.7.4.7"
                     /GO_function="GO:0008902 - hydroxymethylpyrimidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008972 - phosphomethylpyrimidine kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=28413
     Region          1..266
                     /region_name="PRK06427"
                     /note="bifunctional hydroxy-methylpyrimidine kinase/
                     hydroxy-phosphomethylpyrimidine kinase; Reviewed"
                     /db_xref="CDD:180561"
     Site            order(5,12,14..15,17,21,24..25,28,31..36,38,41..45,50..51,
                     53,55..56,59,62,66..67)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238574"
     Site            order(11,23,44,80,213)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:238574"
     Site            order(105,142,176,210,212)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:238574"
ORIGIN      
        1 mqrinaltia gtdpsggagi qadlktfsal gaygcsvita lvaqntcgvq svyriepdfv
       61 aaqldsvfsd vridttkigm laetdiveav aerlqrhhvr nvvldtvmla ksgdpllsps
      121 aietlrvrll pqvslitpnl peaaalldap harteqemla qgrallamgc eavlmkgghl
      181 edaqspdwlf tregeqrfsa prvntknthg tgctlsaala alrprhrswg etvneakawl
      241 saalaqadtl evgkgigpvh hfhaww