MFS transporter [Escherichia coli].

LOCUS       WP_001183177             443 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_001183177
VERSION     WP_001183177.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 443)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 443)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 443)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022776
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     Protein         1..443
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=48550
     Region          20..418
                     /region_name="MFS_SV2_like"
                     /note="Metazoan Synaptic vesicle glycoprotein 2 (SV2) and
                     related small molecule transporters of the Major
                     Facilitator Superfamily; cd17316"
                     /db_xref="CDD:340874"
     Site            order(30..31,34..35,38,70,120..121,123..125,128,148,
                     151..152,155,252,255..256,259..261,264,292,296,347..348,
                     352,356,372,375..376,379..380,383)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340874"
ORIGIN      
        1 mqpsrnfddl kfssihrril lwgsggpfld gyilvmigva leqltpalkl dadwigllga
       61 gtlaglfvgt slfgyisdkv grrkmflidi iaigvisvat mfvsspvell vmrvligivi
      121 gadypiatsm itefsstrqr afsisfiaam wyvgatcadl vgywlydveg gwrwmlgsaa
      181 ipclliligr felpesprwl lrkgrvkece emmiklfgep vafdeeqpqq trfrdlfnrr
      241 hfpfvlfvaa iwtcqvipmf aiytfgpqiv gllglgvgkn aalgnvvisl ffmlgcippm
      301 lwlntagrrp lligsfammt lalavlglip dmgiwlvvma favyaffsgg pgnlqwlypn
      361 elfptdiras avgvimslsr igtivstwal pifinnygis ntmlmgagis lfgllisvaf
      421 apetrgmsla qtsnmtirgq rmg