MULTISPECIES: hydroxyethylthiazole kinase [Salmonella].

LOCUS       WP_001182156             265 aa            linear   BCT 11-MAR-2024
ACCESSION   WP_001182156
VERSION     WP_001182156.1
KEYWORDS    RefSeq.
SOURCE      Salmonella
  ORGANISM  Salmonella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 265)
  AUTHORS   Drebes,J., Kunz,M., Windshugel,B., Kikhney,A.G., Muller,I.B.,
            Eberle,R.J., Oberthur,D., Cang,H., Svergun,D.I., Perbandt,M.,
            Betzel,C. and Wrenger,C.
  TITLE     Structure of ThiM from Vitamin B1 biosynthetic pathway of
            Staphylococcus aureus - Insights into a novel pro-drug approach
            addressing MRSA infections
  JOURNAL   Sci Rep 6, 22871 (2016)
   PUBMED   26960569
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 265)
  AUTHORS   Campobasso,N., Mathews,I.I., Begley,T.P. and Ealick,S.E.
  TITLE     Crystal structure of 4-methyl-5-beta-hydroxyethylthiazole kinase
            from Bacillus subtilis at 1.5 A resolution
  JOURNAL   Biochemistry 39 (27), 7868-7877 (2000)
   PUBMED   10891066
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF006830.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK09355
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Salmonella"
                     /db_xref="taxon:590"
     gene            1..265
                     /gene="thiM"
     Protein         1..265
                     /product="hydroxyethylthiazole kinase"
                     /EC_number="2.7.1.50"
                     /GO_function="GO:0004417 - hydroxyethylthiazole kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=27291
     Region          11..259
                     /region_name="PRK09355"
                     /note="hydroxyethylthiazole kinase; Validated"
                     /db_xref="CDD:236477"
     Site            order(30,32,38,42,48,50,70,72..73)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:238575"
     Site            order(31..36,38..39,42,50..53,55..56,59..60,72..75,
                     108..109,194..197,243..244,246..248,250..251,254)
                     /site_type="other"
                     /note="multimerization interface [polypeptide binding]"
                     /db_xref="CDD:238575"
     Site            order(99,125,127,130,171,173,175,193,199,201)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:238575"
ORIGIN      
        1 mqpdlhcrtl aahtlkhfra lsplthcmtn dvvqtftant llalgaspam vidpvearpf
       61 aaianallin vgtltasrad amraavesay daktpwtldp vavgalefrr rfcldllslr
      121 paairgnase ilalsgmalg grgvdtteaa laalpaaqal arqidcivvv tgeidyvtng
      181 qrtlsipggd plmtrivgtg calsavvaas calpgaaldn vasaccwmkl agqaaaerse
      241 gpgsfipafl dalyhldvea anatn