MULTISPECIES: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

LOCUS       WP_001166395             316 aa            linear   BCT 16-DEC-2020
            [Enterobacteriaceae].
ACCESSION   WP_001166395
VERSION     WP_001166395.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF002188.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK01045
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..316
                     /gene="ispH"
                     /gene_synonym="lytB"
     Protein         1..316
                     /product="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /EC_number="1.17.7.4"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051745 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate reductase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /GO_process="GO:0050992 - dimethylallyl diphosphate
                     biosynthetic process [Evidence IEA]"
                     /calculated_mol_wt=34644
     Region          1..301
                     /region_name="ispH"
                     /note="4-hydroxy-3-methylbut-2-enyl diphosphate reductase;
                     Reviewed; PRK01045"
                     /db_xref="CDD:234893"
     Site            order(12,96,197)
                     /site_type="other"
                     /note="Fe-S cluster binding site [ion binding]"
                     /db_xref="CDD:260116"
     Site            order(15,40..41,73..74,124,126,167..168,224..227,269)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:260116"
     Site            order(124,126,225,227)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:260116"
ORIGIN      
        1 mqillanprg fcagvdrais ivenalaiyg apiyvrhevv hnryvvdslr ergaifieqi
       61 sevpdgaili fsahgvsqav rneaksrdlt vfdatcplvt kvhmevaras rrgeesilig
      121 haghpevegt mgqysnpegg mylvespddv wkltvkneek lsfmtqttls vddtsdvida
      181 lrkrfpkivg prkddicyat tnrqeavral aeqaevvlvv gsknssnsnr laelaqrmgk
      241 rafliddakd iqeewvkevk cvgvtagasa pdilvqnvva rlqqlgggea iplegreeni
      301 vfevpkelrv direvd