MULTISPECIES: leucine--tRNA ligase [Shigella].

LOCUS       WP_001157892             860 aa            linear   BCT 23-MAY-2024
ACCESSION   WP_001157892
VERSION     WP_001157892.1
KEYWORDS    RefSeq.
SOURCE      Shigella
  ORGANISM  Shigella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 860)
  AUTHORS   Liu,Y., Liao,J., Zhu,B., Wang,E.D. and Ding,J.
  TITLE     Crystal structures of the editing domain of Escherichia coli
            leucyl-tRNA synthetase and its complexes with Met and Ile reveal a
            lock-and-key mechanism for amino acid discrimination
  JOURNAL   Biochem J 394 (Pt 2), 399-407 (2006)
   PUBMED   16277600
REFERENCE   2  (residues 1 to 860)
  AUTHORS   Fukunaga,R. and Yokoyama,S.
  TITLE     Aminoacylation complex structures of leucyl-tRNA synthetase and
            tRNALeu reveal two modes of discriminator-base recognition
  JOURNAL   Nat Struct Mol Biol 12 (10), 915-922 (2005)
   PUBMED   16155584
REFERENCE   3  (residues 1 to 860)
  AUTHORS   Zhao,M.W., Zhu,B., Hao,R., Xu,M.G., Eriani,G. and Wang,E.D.
  TITLE     Leucyl-tRNA synthetase from the ancestral bacterium Aquifex
            aeolicus contains relics of synthetase evolution
  JOURNAL   EMBO J 24 (7), 1430-1439 (2005)
   PUBMED   15775966
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00396.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..860
                     /organism="Shigella"
                     /db_xref="taxon:620"
     gene            1..860
                     /gene="leuS"
     Protein         1..860
                     /product="leucine--tRNA ligase"
                     /EC_number="6.1.1.4"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004823 - leucine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006429 - leucyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /calculated_mol_wt=97120
     Region          1..860
                     /region_name="LeuS"
                     /note="Leucyl-tRNA synthetase [Translation, ribosomal
                     structure and biogenesis]; COG0495"
                     /db_xref="CDD:440261"
ORIGIN      
        1 mqeqyrpeei eskvqlhwde krtfevtede skekyyclsm lpypsgrlhm ghvrnytigd
       61 viaryqrmlg knvlqpigwd afglpaegaa vknntapapw tydniaymkn qlkmlgfgyd
      121 wsrelatctp eyyrweqkff telykkglvy kktsavnwcp ndqtvlaneq vidgccwrcd
      181 tkverkeipq wfikitayad ellndldkld hwpdtvktmq rnwigrsegv eitfnvndyd
      241 ntltvyttrp dtfmgctyla vaaghplaqk aaennpelaa fidecrntkv aeaematmek
      301 kgvdtgfkav hpltgeeipv waanfvlmey gtgavmavpg hdqrdyefas kyglnikpvi
      361 laadgsepdl sqqaltekgv lfnsgefngl dheaafnaia dkltamgvge rkvnyrlrdw
      421 gvsrqrywga pipmvtledg tvmptpddql pvilpedvvm dgitspikad pewakttvng
      481 mpalretdtf dtfmesswyy arytcpeyke gmldseaany wlpvdiyigg iehaimhlly
      541 frffhklmrd agmvnsdepa kqllcqgmvl adafyyvgen gernwvspvd aiverdekgr
      601 ivkakdaagh elvytgmskm sksknngidp qvmverygad tvrlfmmfas padmtlewqe
      661 sgveganrfl krvwklvyeh takgdvaaln vdaltedqka lrrdvhktia kvtddigrrq
      721 tfntaiaaim elmnklakap tdgeqdralm qealqavvrm lnpftphicf tlwqelkgeg
      781 didnapwpva dekamvedst lvvvqvngkv rakitvpvda teeqvrerag qehlvakyld
      841 gvtvrkviyv pgkllnlvvg