MFS transporter [Escherichia coli].

LOCUS       WP_001149004             440 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_001149004
VERSION     WP_001149004.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 440)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 440)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 440)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13024289
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     Protein         1..440
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=47107
     Region          22..431
                     /region_name="MFS_ShiA_like"
                     /note="Shikimate transporter and similar proteins of the
                     Major Facilitator Superfamily; cd17369"
                     /db_xref="CDD:340927"
     Site            order(34..35,38..39,42,81,139..140,142..144,147,167,
                     170..171,174,257,260..261,264..266,269,301,305,358..359,
                     363,367,383,386..387,390..391,394)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340927"
ORIGIN      
        1 mqatattldh eqeytpinsr nkvlvaslig taieffdfyi yataavivfp hiffpqgdpt
       61 aatlqslatf aiafvarpig savfghfgdr vgrkatlvas lltmgistvv igllpgyati
      121 gifaplllal arfgqglglg gewggaalla tenapprkra lygsfpqlga pigfffangt
      181 flllswlltd eqfmswgwrv pfifsavlvi iglyvrvslh espvfekvak akkqvkiplg
      241 tlltkhvrvt vlgtfimlat ytlfyimtvy smtfstaaap vglglprnev lwmlmmavig
      301 fgvmvpvagl ladafgrrks mviittliil falfafnpll gsgnpilvfa flllglslmg
      361 ltfgpmgall pelfptevry tgasfsynva silgasvapy iaawlqtnyg lsavglylaa
      421 magltliall lthetrhqsl