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LOCUS WP_001145331 699 aa linear BCT 24-DEC-2024 cyclase/phosphodiesterase [Salmonella]. ACCESSION WP_001145331 VERSION WP_001145331.1 KEYWORDS RefSeq. SOURCE Salmonella ORGANISM Salmonella Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae. REFERENCE 1 (residues 1 to 699) AUTHORS Romling,U. and Amikam,D. TITLE Cyclic di-GMP as a second messenger JOURNAL Curr Opin Microbiol 9 (2), 218-228 (2006) PUBMED 16530465 REFERENCE 2 (residues 1 to 699) AUTHORS Romling,U., Gomelsky,M. and Galperin,M.Y. TITLE C-di-GMP: the dawning of a novel bacterial signalling system JOURNAL Mol Microbiol 57 (3), 629-639 (2005) PUBMED 16045609 REFERENCE 3 (residues 1 to 699) AUTHORS Simm,R., Morr,M., Kader,A., Nimtz,M. and Romling,U. TITLE GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility JOURNAL Mol Microbiol 53 (4), 1123-1134 (2004) PUBMED 15306016 REFERENCE 4 (residues 1 to 699) AUTHORS Galperin,M.Y., Nikolskaya,A.N. and Koonin,E.V. TITLE Novel domains of the prokaryotic two-component signal transduction systems JOURNAL FEMS Microbiol Lett 203 (1), 11-21 (2001) PUBMED 11557134 REMARK Erratum:[FEMS Microbiol Lett 2001 Oct 16;204(1):213-4] COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 11472025 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..699 /organism="Salmonella" /db_xref="taxon:590" Protein 1..699 /product="putative bifunctional diguanylate cyclase/phosphodiesterase" /EC_number="2.7.7.65" /GO_component="GO:0005886 - plasma membrane [Evidence IEA]" /GO_function="GO:0005525 - GTP binding [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /GO_function="GO:0052621 - diguanylate cyclase activity [Evidence IEA]" /GO_function="GO:0071111 - cyclic-guanylate-specific phosphodiesterase activity [Evidence IEA]" /calculated_mol_wt=76571 Region 10..686 /region_name="COG5001" /note="Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain [Signal transduction mechanisms]" /db_xref="CDD:444025" ORIGIN 1 mpvseynhil vavsfavaif asytalnmag rvagsarsna riwlmgggfa lgvgiwamhf 61 vgmlamdham nmrfdpfltg lsmliaigss lfalwlvsae klrlrrllpg alvmglgisa 121 mhytgmaalq fasiivwnsa wvalsiiial lascgalwlt frlrhegtdv alrragaavl 181 mgiaiagmhy agmkaahfpq nwpmehrgvd snwlavlvsv valtilgitl lvslfdarlq 241 artallassl aqanqelaql alhdtltrlp nrvlledrle qaiskanren tsfallfmdl 301 dgfktvnday ghdigdkllv avthrlnqpl sgqftlarig gdefvllaev sapdeaasla 361 salvhsidap ftidpyelvv tlsvgialyp ldgknerelm fnadaamyht khtgrngyhf 421 fqpsmnmlaq tqlqlmndlw lalerqelrl vyqpkfqapa gpivgfeall rwyhpkqgvl 481 npdqflplae ktglivtigs wvideacrql rewhlqgydl wsvavnlsal qfeqpglvdt 541 itrslarhsi rpdllileit ettamnkpeq svailtrlte mgvkasiddf gtgyssllyl 601 krlpacelki drafvhelse agdgativaa ivalakalnl qivaegvene tqqqfltqlg 661 chtlqgfllg kprtaeeiar dirdpanift rsiyninsk