SDR family oxidoreductase [Escherichia coli].

LOCUS       WP_001136533             476 aa            linear   BCT 21-JUL-2024
ACCESSION   WP_001136533
VERSION     WP_001136533.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 476)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
REFERENCE   2  (residues 1 to 476)
  AUTHORS   Kavanagh,K.L., Jornvall,H., Persson,B. and Oppermann,U.
  TITLE     Medium- and short-chain dehydrogenase/reductase gene and protein
            families : the SDR superfamily: functional and structural diversity
            within a family of metabolic and regulatory enzymes
  JOURNAL   Cell Mol Life Sci 65 (24), 3895-3906 (2008)
   PUBMED   19011750
REFERENCE   3  (residues 1 to 476)
  AUTHORS   Oppermann,U., Filling,C., Hult,M., Shafqat,N., Wu,X., Lindh,M.,
            Shafqat,J., Nordling,E., Kallberg,Y., Persson,B. and Jornvall,H.
  TITLE     Short-chain dehydrogenases/reductases (SDR): the 2002 update
  JOURNAL   Chem Biol Interact 143-144, 247-253 (2003)
   PUBMED   12604210
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10142831
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     Protein         1..476
                     /product="SDR family oxidoreductase"
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /calculated_mol_wt=53792
     Region          5..296
                     /region_name="SDR_a2"
                     /note="atypical (a) SDRs, subgroup 2; cd05245"
                     /db_xref="CDD:187556"
     Site            order(9,11..12,14,33..35,73..75,109..111,122,126,145..148)
                     /site_type="other"
                     /note="putative NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187556"
     Site            order(122,126)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:187556"
     Region          334..463
                     /region_name="DUF2867"
                     /note="Protein of unknown function (DUF2867); pfam11066"
                     /db_xref="CDD:431633"
ORIGIN      
        1 mpqrilvlga sgyigqhlvr tlsqqghqil aaarhvdrla klqlanvsch kvdlswpdnl
       61 pallqdidtv yflvhsmgeg gdfiaqerqv alnfrdalre vpvkqlifls slqappheqs
      121 dhlrarqata dilreanvpv telragiivg agsaafevmr dmvynlpvlt pprwvrsrtt
      181 pialenllhy lvalldhpan ehrifeaagp evlsyqqqfe hfmavsgkrr wlipiplptr
      241 wisvwflnvi tsvppttara liqglkhdll addtalrali pqrliafdda vrrtlkeeek
      301 lvnssdwgyd tqafarwrpe ygyfakqagf tvktsaslaa lwqvvnqigg keryffgnil
      361 wqtralmdra ighklakgrp ereylqtgda vdswkvivve pekqltllfg mkapglgrlc
      421 ftledkgdyr tidvrafwhp hgmpglfywl lmipahlfif rgmakriarl aeqstd