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efflux RND transporter permease AcrB [Escherichia coli].


LOCUS       WP_001132452            1049 aa            linear   BCT 30-AUG-2021
ACCESSION   WP_001132452
VERSION     WP_001132452.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 1049)
  AUTHORS   Hobbs,E.C., Yin,X., Paul,B.J., Astarita,J.L. and Storz,G.
  TITLE     Conserved small protein associates with the multidrug efflux pump
            AcrB and differentially affects antibiotic resistance
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16696-16701 (2012)
   PUBMED   23010927
REFERENCE   2  (residues 1 to 1049)
  AUTHORS   Aoki,S.K., Malinverni,J.C., Jacoby,K., Thomas,B., Pamma,R.,
            Trinh,B.N., Remers,S., Webb,J., Braaten,B.A., Silhavy,T.J. and
            Low,D.A.
  TITLE     Contact-dependent growth inhibition requires the essential outer
            membrane protein BamA (YaeT) as the receptor and the inner membrane
            transport protein AcrB
  JOURNAL   Mol Microbiol 70 (2), 323-340 (2008)
   PUBMED   18761695
REFERENCE   3  (residues 1 to 1049)
  AUTHORS   Sennhauser,G., Amstutz,P., Briand,C., Storchenegger,O. and
            Grutter,M.G.
  TITLE     Drug export pathway of multidrug exporter AcrB revealed by DARPin
            inhibitors
  JOURNAL   PLoS Biol 5 (1), e7 (2007)
   PUBMED   17194213
REFERENCE   4  (residues 1 to 1049)
  AUTHORS   Seeger,M.A., Schiefner,A., Eicher,T., Verrey,F., Diederichs,K. and
            Pos,K.M.
  TITLE     Structural asymmetry of AcrB trimer suggests a peristaltic pump
            mechanism
  JOURNAL   Science 313 (5791), 1295-1298 (2006)
   PUBMED   16946072
REFERENCE   5  (residues 1 to 1049)
  AUTHORS   Murakami,S., Nakashima,R., Yamashita,E. and Yamaguchi,A.
  TITLE     Crystal structure of bacterial multidrug efflux transporter AcrB
  JOURNAL   Nature 419 (6907), 587-593 (2002)
   PUBMED   12374972
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR011128
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1049
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..1049
                     /gene="acrB"
     Protein         1..1049
                     /product="efflux RND transporter permease AcrB"
                     /calculated_mol_wt=113484
     Region          1..1049
                     /region_name="PRK15127"
                     /note="multidrug efflux RND transporter permease subunit
                     AcrB"
                     /db_xref="CDD:185081"
ORIGIN      
        1 mpnffidrpi fawviaiiim lagglailkl pvaqyptiap pavtisasyp gadaktvqdt
       61 vtqvieqnmn gidnlmymss nsdstgtvqi tltfesgtda diaqvqvqnk lqlampllpq
      121 evqqqgvsie kssssflmvv gvintdgtmt qedisdyvaa nmkdaisrts gvgdvqlfgs
      181 qyamriwmnp nelnkfqltp vdvitaikaq naqvaagqlg gtppvkgqql nasiiaqtrl
      241 tsteefgkil lkvnqdgsrv llrdvakiel ggenydiiae fngqpasglg iklatganal
      301 dtaaairael akmepffpsg lkivypydtt pfvkisihev vktlveaiil vflvmylflq
      361 nfratlipti avpvvllgtf avlaafgfsi ntltmfgmvl aigllvddai vvvenvervm
      421 aeeglppkea trksmgqiqg alvgiamvls avfvpmaffg gstgaiyrqf sitivsamal
      481 svlvaliltp alcatmlkpi akgdhgegkk gffgwfnrmf eksthhytds vggilrstgr
      541 ylvlyliivv gmaylfvrlp ssflpdedqg vfmtmvqlpa gatqertqkv lnevthyylt
      601 keknnvesvf avngfgfagr gqntgiafvs lkdwadrpge enkveaitmr atrafsqikd
      661 amvfafnlpa ivelgtatgf dfelidqagl ghekltqarn qllaeaakhp dmltsvrpng
      721 ledtpqfkid idqekaqalg vsindinttl gaawggsyvn dfidrgrvkk vyvmseakyr
      781 mlpddigdwy vraadgqmvp fsafsssrwe ygsprleryn glpsmeilgq aapgkstgea
      841 melmeqlask lptgvgydwt gmsyqerlsg nqapslyais livvflclaa lyeswsipfs
      901 vmlvvplgvi gallaatfrg ltndvyfqvg llttiglsak nailivefak dlmdkegkgl
      961 ieatldavrm rlrpilmtsl afilgvmplv istgagsgaq navgtgvmgg mvtatvlaif
     1021 fvpvffvvvr rrfsrknedi ehnhtvdhh