MFS transporter [Escherichia coli].

LOCUS       WP_001127211             457 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_001127211
VERSION     WP_001127211.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 457)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 457)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 457)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022956
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     Protein         1..457
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=48017
     Region          21..451
                     /region_name="MFS_MMR_MDR_like"
                     /note="Methylenomycin A resistance protein (also called
                     MMR peptide) and similar multidrug resistance (MDR)
                     transporters of the Major Facilitator Superfamily;
                     cd17321"
                     /db_xref="CDD:340879"
     Site            order(28..29,32..33,36,68,118..119,121..123,126,146,
                     149..150,153,277,280..281,284..286,289,317,321,373..374,
                     378,382,398,401..402,405..406,409)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340879"
ORIGIN      
        1 mpkvqadglp lpqrygailt ivigismavl dgaianvalp tiatdlhatp assiwvvnay
       61 qiaivislls fsflgdmfgy rriykcglvv fllsslfcal sdslqiltla rviqgfggaa
      121 lmsvntalir liypqrflgr gmginsfiva vssaagptia aailsiaswk wlflinvplg
      181 iialllamrf lppngsrask prfdlpsavm naltfgllit alsgfaqgqs ltliaaelvv
      241 mvvvgiffir rqlslpvpll pvdllriplf slsictsvcs fcaqmlamvs lpfylqtvlg
      301 rsevetglll tpwplatmvm aplagylier vhagllgalg lfimaaglfs lvllpaspad
      361 iniiwpmilc gagfglfqsp nnhtiitsap rersggasgm lgtarllgqs sgaalvalml
      421 nqfgdngthv slmaaailav iaacisglri tqprsra