MULTISPECIES: carbamoyl-phosphate synthase large subunit

LOCUS       WP_001126371            1073 aa            linear   BCT 07-MAY-2024
            [Enterobacteriaceae].
ACCESSION   WP_001126371
VERSION     WP_001126371.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 1073)
  AUTHORS   Thoden,J.B., Huang,X., Kim,J., Raushel,F.M. and Holden,H.M.
  TITLE     Long-range allosteric transitions in carbamoyl phosphate synthetase
  JOURNAL   Protein Sci 13 (9), 2398-2405 (2004)
   PUBMED   15322282
REFERENCE   2  (residues 1 to 1073)
  AUTHORS   Miles,B.W., Thoden,J.B., Holden,H.M. and Raushel,F.M.
  TITLE     Inactivation of the amidotransferase activity of carbamoyl
            phosphate synthetase by the antibiotic acivicin
  JOURNAL   J Biol Chem 277 (6), 4368-4373 (2002)
   PUBMED   11729189
REFERENCE   3  (residues 1 to 1073)
  AUTHORS   Thoden,J.B., Raushel,F.M., Benning,M.M., Rayment,I. and Holden,H.M.
  TITLE     The structure of carbamoyl phosphate synthetase determined to 2.1 A
            resolution
  JOURNAL   Acta Crystallogr D Biol Crystallogr 55 (Pt 1), 8-24 (1999)
   PUBMED   10089390
REFERENCE   4  (residues 1 to 1073)
  AUTHORS   Thoden,J.B., Holden,H.M., Wesenberg,G., Raushel,F.M. and Rayment,I.
  TITLE     Structure of carbamoyl phosphate synthetase: a journey of 96 A from
            substrate to product
  JOURNAL   Biochemistry 36 (21), 6305-6316 (1997)
   PUBMED   9174345
REFERENCE   5  (residues 1 to 1073)
  AUTHORS   Trotta,P.P., Pinkus,L.M., Haschemeyer,R.H. and Meister,A.
  TITLE     Reversible dissociation of the monomer of glutamine-dependent
            carbamyl phosphate synthetase into catalytically active heavy and
            light subunits
  JOURNAL   J Biol Chem 249 (2), 492-499 (1974)
   PUBMED   4358555
REFERENCE   6  (residues 1 to 1073)
  AUTHORS   Khedouri,E., Anderson,P.M. and Meister,A.
  TITLE     Selective inactivation of the glutamine binding site of Escherichia
            coli carbamyl phosphate synthetase by
            2-amino-4-oxo-5-chloropentanoic acid
  JOURNAL   Biochemistry 5 (11), 3552-3557 (1966)
   PUBMED   5339592
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF003671.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK05294
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1073
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..1073
                     /gene="carB"
     Protein         1..1073
                     /product="carbamoyl-phosphate synthase large subunit"
                     /EC_number="6.3.5.5"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence
                     IEA]"
                     /calculated_mol_wt=117725
     Region          1..1069
                     /region_name="carB"
                     /note="carbamoyl-phosphate synthase large subunit;
                     PRK05294"
                     /db_xref="CDD:235393"
ORIGIN      
        1 mpkrtdiksi lilgagpivi gqacefdysg aqackalree gyrvilvnsn patimtdpem
       61 adatyiepih wevvrkiiek erpdavlptm ggqtalncal elerqgvlee fgvtmigata
      121 daidkaedrr rfdvamkkig letarsgiah tmeealavaa dvgfpciirp sftmggsggg
      181 iaynreefee icargldlsp tkellidesl igwkeyemev vrdkndncii vcsienfdam
      241 gihtgdsitv apaqtltdke yqimrnasma vlreigvetg gsnvqfavnp kngrliviem
      301 nprvsrssal askatgfpia kvaaklavgy tldelmndit ggrtpasfep sidyvvtkip
      361 rfnfekfaga ndrlttqmks vgevmaigrt qqeslqkalr glevgatgfd pkvslddpea
      421 ltkirrelkd agaeriwyia dafraglsvd gvfnltnidr wflvqieelv rleekvaevg
      481 itglnaeflr qlkrkgfada rlaklagvre aeirklrdqy dlhpvykrvd tcaaefatdt
      541 aymystyeee ceanpstdre kimvlgggpn rigqgiefdy ccvhaslalr edgyetimvn
      601 cnpetvstdy dtsdrlyfep vtledvleiv riekpkgviv qyggqtplkl araleaagvp
      661 vigtspdaid raedrerfqh avdrlklkqp anatvtaiem avekakeigy plvvrpsyvl
      721 ggrameivyd eadlrryfqt avsvsndapv lldhflddav evdvdaicdg emvliggime
      781 hieqagvhsg dsacslpayt lsqeiqdvmr qqvqklafel qvrglmnvqf avknnevyli
      841 evnpraartv pfvskatgvp lakvaarvma gkslaeqgvt kevippyysv kevvlpfnkf
      901 pgvdpllgpe mrstgevmgv grtfaeafak aqlgsnstmk khgrallsvr egdkervvdl
      961 aakllkqgfe ldathgtaiv lgeaginprl vnkvhegrph iqdrikngey tyiinttsgr
     1021 raiedsrvir rsalqykvhy dttlnggfat amalnadate kvisvqemha qik