MULTISPECIES: type II toxin-antitoxin system serine/threonine

LOCUS       WP_001125439             440 aa            linear   BCT 16-DEC-2020
            protein kinase toxin HipA [Enterobacteriaceae].
ACCESSION   WP_001125439
VERSION     WP_001125439.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 440)
  AUTHORS   Schumacher,M.A., Balani,P., Min,J., Chinnam,N.B., Hansen,S.,
            Vulic,M., Lewis,K. and Brennan,R.G.
  TITLE     HipBA-promoter structures reveal the basis of heritable multidrug
            tolerance
  JOURNAL   Nature 524 (7563), 59-64 (2015)
   PUBMED   26222023
REFERENCE   2  (residues 1 to 440)
  AUTHORS   Schumacher,M.A., Piro,K.M., Xu,W., Hansen,S., Lewis,K. and
            Brennan,R.G.
  TITLE     Molecular mechanisms of HipA-mediated multidrug tolerance and its
            neutralization by HipB
  JOURNAL   Science 323 (5912), 396-401 (2009)
   PUBMED   19150849
REFERENCE   3  (residues 1 to 440)
  AUTHORS   Korch,S.B. and Hill,T.M.
  TITLE     Ectopic overexpression of wild-type and mutant hipA genes in
            Escherichia coli: effects on macromolecular synthesis and persister
            formation
  JOURNAL   J. Bacteriol. 188 (11), 3826-3836 (2006)
   PUBMED   16707675
REFERENCE   4  (residues 1 to 440)
  AUTHORS   Black,D.S., Irwin,B. and Moyed,H.S.
  TITLE     Autoregulation of hip, an operon that affects lethality due to
            inhibition of peptidoglycan or DNA synthesis
  JOURNAL   J. Bacteriol. 176 (13), 4081-4091 (1994)
   PUBMED   8021189
REFERENCE   5  (residues 1 to 440)
  AUTHORS   Moyed,H.S. and Bertrand,K.P.
  TITLE     hipA, a newly recognized gene of Escherichia coli K-12 that affects
            frequency of persistence after inhibition of murein synthesis
  JOURNAL   J. Bacteriol. 155 (2), 768-775 (1983)
   PUBMED   6348026
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            REFSEQ INFORMATION: The reference sequence is identical to
            AAC74580.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR008157
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..440
                     /gene="hipA"
     Protein         1..440
                     /product="type II toxin-antitoxin system serine/threonine
                     protein kinase toxin HipA"
                     /EC_number="2.7.11.1"
                     /calculated_mol_wt=49145
     Region          20..435
                     /region_name="HipA_Ec_like"
                     /note="type II toxin-antitoxin sytem toxin HipA from
                     Escherichia coli and similar proteins; cd17808"
                     /db_xref="CDD:341493"
     Site            order(21..24,55,58,67,69..70,73,76..77,80,84..85)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:341493"
     Site            order(36..38,46,48..49,285..286,288..289,322..324,382,384,
                     387)
                     /site_type="other"
                     /note="HipB interaction site [polypeptide binding]"
                     /db_xref="CDD:341493"
     Site            order(151..155,157,179,181,218,233..237,252,309,311,
                     313..314,316,331..332)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:341493"
ORIGIN      
        1 mpklvtwmnn qrvgeltkla ngahtfkyap ewlasryarp lslslplqrg nitsdavfnf
       61 fdnllpdspi vrdrivkryh aksrqpfdll seigrdsvga vtlipedetv thpimawekl
      121 tearleevlt aykadiplgm ireendfris vagaqektal lrigndwcip kgitptthii
      181 klpigeirqp natldlsqsv dneyycllla kelglnvpda eiikagnvra laverfdrrw
      241 naertvllrl pqedmcqtfg lpssvkyesd ggpgiarima flmgssealk drydfmkfqv
      301 fqwligatdg haknfsvfiq aggsyrltpf ydiisafpvl ggtgihisdl klamglnask
      361 gkktaidkiy prhflatakv lrfpevqmhe ilsdfarmip aaldnvktsl ptdfpenvvt
      421 avesnvlrlh grlsreygsk