RNA-splicing ligase RtcB [Escherichia coli].

LOCUS       WP_001105473             408 aa            linear   BCT 24-FEB-2020
ACCESSION   WP_001105473
VERSION     WP_001105473.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 408)
  AUTHORS   Maughan,W.P. and Shuman,S.
  TITLE     Distinct Contributions of Enzymic Functional Groups to the
            2',3'-Cyclic Phosphodiesterase, 3'-Phosphate Guanylylation, and
            3'-ppG/5'-OH Ligation Steps of the Escherichia coli RtcB Nucleic
            Acid Splicing Pathway
  JOURNAL   J. Bacteriol. 198 (8), 1294-1304 (2016)
   PUBMED   26858100
REFERENCE   2  (residues 1 to 408)
  AUTHORS   Chakravarty,A.K. and Shuman,S.
  TITLE     The sequential 2',3'-cyclic phosphodiesterase and
            3'-phosphate/5'-OH ligation steps of the RtcB RNA splicing pathway
            are GTP-dependent
  JOURNAL   Nucleic Acids Res. 40 (17), 8558-8567 (2012)
   PUBMED   22730297
REFERENCE   3  (residues 1 to 408)
  AUTHORS   Chakravarty,A.K., Subbotin,R., Chait,B.T. and Shuman,S.
  TITLE     RNA ligase RtcB splices 3'-phosphate and 5'-OH ends via covalent
            RtcB-(histidinyl)-GMP and polynucleotide-(3')pp(5')G intermediates
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 109 (16), 6072-6077 (2012)
   PUBMED   22474365
REFERENCE   4  (residues 1 to 408)
  AUTHORS   Tanaka,N., Chakravarty,A.K., Maughan,B. and Shuman,S.
  TITLE     Novel mechanism of RNA repair by RtcB via sequential 2',3'-cyclic
            phosphodiesterase and 3'-Phosphate/5'-hydroxyl ligation reactions
  JOURNAL   J. Biol. Chem. 286 (50), 43134-43143 (2011)
   PUBMED   22045815
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR011253
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..408
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..408
                     /gene="rtcB"
     Protein         1..408
                     /product="RNA-splicing ligase RtcB"
                     /EC_number="6.5.1.8"
                     /calculated_mol_wt=45107
     Region          8..408
                     /region_name="RtcB"
                     /note="RNA-splicing ligase RtcB, repairs tRNA damage
                     [Translation, ribosomal structure and biogenesis];
                     COG1690"
                     /db_xref="CDD:441296"
ORIGIN      
        1 mnyelltten apvkmwtkgv pveadarqql intakmpfif khiavmpdvh lgkgstigsv
       61 iptkgaiipa avgvdigcgm nalrtaltaa dlpenlaelr qaietavphg rttgrckrdk
      121 gawenppvnv dakwaeleag yqwltqkypr flntnnykhl gtlgtgnhfi eicldesdqv
      181 wimlhsgsrg ignaigtyfi dlaqkemqet letlpsrdla yfmegteyfd dylkavawaq
      241 lfaslnrdvm menvvtalqs itqktvrqpq tlameeinch hnyvqkeqhf geeiyvtrkg
      301 avsaragqyg iipgsmgaks fivrglgnee sfcscshgag rvmsrtkakk mfsvedqira
      361 tvhvecrkda evideipmay kdidavmaaq sdlveviytl rqvvcvkg