MFS transporter [Escherichia coli].

LOCUS       WP_001098105             445 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_001098105
VERSION     WP_001098105.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 445)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 445)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 445)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13022776
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     Protein         1..445
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=48103
     Region          23..419
                     /region_name="MFS_SV2_like"
                     /note="Metazoan Synaptic vesicle glycoprotein 2 (SV2) and
                     related small molecule transporters of the Major
                     Facilitator Superfamily; cd17316"
                     /db_xref="CDD:340874"
     Site            order(31..32,35..36,39,71,121..122,124..126,129,149,
                     152..153,156,256,259..260,263..265,268,293,297,347..348,
                     352,356,372,375..376,379..380,383)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340874"
ORIGIN      
        1 mntspvrmdd lplnrfhcri aaltfgahlt dgyvlgvigy aiiqltpamq ltpfmagmig
       61 gsallglflg slvlgwisdh igrqkiftfs fllitlasfl qffattpehl iglriligig
      121 lggdysvght llaefsprrh rgillgafsv vwtvgyvlas iaghhfisen peawrwllas
      181 aalpallitl lrwgtpespr wllrqgrfae ahaivhryfg phvllgdevv tathkhiktl
      241 fssrywrrta fnsvffvclv ipwfviytwl ptiaqtigle daltaslmln allivgallg
      301 lvlthllahr kfllgsflll aatlvvmacl psgssltlll fvlfsttisa vsnlvgilpa
      361 esfptdirsl gvgfatamsr lgaavstgll pwvlaqwgmq vtllllatvl lvgfvvtwlw
      421 apetkalplv aagnvggane hsvsv