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bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase


LOCUS       WP_001086511             702 aa            linear   BCT 25-APR-2022
            RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL
            [Escherichia coli].
ACCESSION   WP_001086511
VERSION     WP_001086511.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 702)
  AUTHORS   Jiang,M., Sullivan,S.M., Walker,A.K., Strahler,J.R., Andrews,P.C.
            and Maddock,J.R.
  TITLE     Identification of novel Escherichia coli ribosome-associated
            proteins using isobaric tags and multidimensional protein
            identification techniques
  JOURNAL   J Bacteriol 189 (9), 3434-3444 (2007)
   PUBMED   17337586
REFERENCE   2  (residues 1 to 702)
  AUTHORS   Sergiev,P.V., Bogdanov,A.A. and Dontsova,O.A.
  TITLE     Ribosomal RNA guanine-(N2)-methyltransferases and their targets
  JOURNAL   Nucleic Acids Res 35 (7), 2295-2301 (2007)
   PUBMED   17389639
REFERENCE   3  (residues 1 to 702)
  AUTHORS   Lesnyak,D.V., Sergiev,P.V., Bogdanov,A.A. and Dontsova,O.A.
  TITLE     Identification of Escherichia coli m2G methyltransferases: I. the
            ycbY gene encodes a methyltransferase specific for G2445 of the 23
            S rRNA
  JOURNAL   J Mol Biol 364 (1), 20-25 (2006)
   PUBMED   17010378
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF008748.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK11783
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..702
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..702
                     /gene="rlmKL"
     Protein         1..702
                     /product="bifunctional 23S rRNA
                     (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA
                     (guanine(2445)-N(2))-methyltransferase RlmL"
                     /EC_number="2.1.1.173"
                     /EC_number="2.1.1.264"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0008990 - rRNA
                     (guanine-N2-)-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0031167 - rRNA methylation [Evidence IEA]"
                     /calculated_mol_wt=78765
     Region          1..702
                     /region_name="rlmL"
                     /note="bifunctional 23S rRNA
                     (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA
                     (guanine(2445)-N(2))-methyltransferase RlmL; PRK11783"
                     /db_xref="CDD:236981"
ORIGIN      
        1 mnslfastar gleellktel enlgavecqv vqggvhfkgd trlvyqslmw srlasrimlp
       61 lgeckvysdl dlylgvqain wtemfnpgat favhfsglnd tirnsqygam kvkdaivdaf
      121 trknlprpnv drdapdirvn vwlhketasi aldlsgdglh lrgyrdragi apiketlaaa
      181 ivmrsgwqpg tplldpmcgs gtllieaaml atdrapglhr grwgfsgwaq hdeaiwqevk
      241 aeaqtrarkg laeysshfyg sdsdarviqr artnarlagi gelitfevkd vaqltnplpk
      301 epygtvlsnp pygerldsep alialhsllg rimknqfggw nlslfsaspd llsclqlrad
      361 kqykakngpl dcvqknyhva estpdskpam vaedyanrlr knlkkfekwa rqegiecyrl
      421 ydadlpeynv avdryadwvv vqeyappkti dahkarqrlf diiaatisvl giapnklvlk
      481 trerqkgknq yqklgekgef levteynahl wvnltdyldt glfldhriar rmlgqmskgk
      541 dflnlfsytg satvhaglgg arstttvdms rtylewaern lrlngltgra hrliqadcla
      601 wlreaneqfd lifidpptfs nskrmedafd vqrdhlalmk dlkrllragg timfsnnkrg
      661 frmdldglak lglkaqeitq ktlsqdfarn rqihncwlit aa