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MULTISPECIES: dTMP kinase [Shigella].

FASTAView on NCBI
LOCUS       WP_001076235             237 aa            linear   BCT 17-NOV-2023
ACCESSION   WP_001076235
VERSION     WP_001076235.1
KEYWORDS    RefSeq.
SOURCE      Shigella
  ORGANISM  Shigella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 237)
  AUTHORS   Reynes,J.P., Tiraby,M., Baron,M., Drocourt,D. and Tiraby,G.
  TITLE     Escherichia coli thymidylate kinase: molecular cloning, nucleotide
            sequence, and genetic organization of the corresponding tmk locus
  JOURNAL   J Bacteriol 178 (10), 2804-2812 (1996)
   PUBMED   8631667
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10109302
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Shigella"
                     /db_xref="taxon:620"
     Protein         1..237
                     /product="dTMP kinase"
                     /EC_number="2.7.4.9"
                     /GO_function="GO:0004798 - thymidylate kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006233 - dTDP biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0006235 - dTTP biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /calculated_mol_wt=26170
     Region          15..234
                     /region_name="TMPK"
                     /note="Thymidine monophosphate kinase (TMPK), also known
                     as thymidylate kinase, catalyzes the phosphorylation of
                     thymidine monophosphate (TMP) to thymidine diphosphate
                     (TDP) utilizing ATP as its preferred phophoryl donor. TMPK
                     represents the rate-limiting step...; cd01672"
                     /db_xref="CDD:238835"
     Site            order(28,100,104,124..125,133,190)
                     /site_type="active"
                     /note="TMP-binding site [active]"
                     /db_xref="CDD:238835"
     Site            order(29,186,217)
                     /site_type="other"
                     /note="ATP-binding site [chemical binding]"
                     /db_xref="CDD:238835"
ORIGIN      
        1 mnqrnmsiin stpvrviaiv gcdgsgkstl taslvnelaa rmptehiylg qssgrigewi
       61 sqlpvigapc gcylrskaah vhekpltppg nitalviyll scwraykfrk mlcksqqgyl
      121 litdrypqve vpgfrfdgpq lakttggngw ikmlrqrelk lyqwmasylp vllirlgide
      181 qtafarkpdh qlaalqekia vtpqltfnga kileldgrqp adeimqaslr aihaals