MULTISPECIES: lipoprotein metalloprotease SslE

LOCUS       WP_001034469            1520 aa            linear   BCT 11-NOV-2019
            [Enterobacteriaceae].
ACCESSION   WP_001034469
VERSION     WP_001034469.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 1520)
  AUTHORS   Tapader,R., Bose,D., Dutta,P., Das,S. and Pal,A.
  TITLE     SslE (YghJ), a Cell-Associated and Secreted Lipoprotein of Neonatal
            Septicemic Escherichia coli, Induces Toll-Like Receptor 2-Dependent
            Macrophage Activation and Proinflammation through NF-kappaB and MAP
            Kinase Signaling
  JOURNAL   Infect. Immun. 86 (9) (2018)
   PUBMED   29891541
REFERENCE   2  (residues 1 to 1520)
  AUTHORS   Tapader,R., Bose,D. and Pal,A.
  TITLE     YghJ, the secreted metalloprotease of pathogenic E. coli induces
            hemorrhagic fluid accumulation in mouse ileal loop
  JOURNAL   Microb. Pathog. 105, 96-99 (2017)
   PUBMED   28212863
REFERENCE   3  (residues 1 to 1520)
  AUTHORS   Valeri,M., Rossi Paccani,S., Kasendra,M., Nesta,B., Serino,L.,
            Pizza,M. and Soriani,M.
  TITLE     Pathogenic E. coli exploits SslE mucinase activity to translocate
            through the mucosal barrier and get access to host cells
  JOURNAL   PLoS ONE 10 (3), e0117486 (2015)
   PUBMED   25789808
REFERENCE   4  (residues 1 to 1520)
  AUTHORS   Baldi,D.L., Higginson,E.E., Hocking,D.M., Praszkier,J.,
            Cavaliere,R., James,C.E., Bennett-Wood,V., Azzopardi,K.I.,
            Turnbull,L., Lithgow,T., Robins-Browne,R.M., Whitchurch,C.B. and
            Tauschek,M.
  TITLE     The type II secretion system and its ubiquitous lipoprotein
            substrate, SslE, are required for biofilm formation and virulence
            of enteropathogenic Escherichia coli
  JOURNAL   Infect. Immun. 80 (6), 2042-2052 (2012)
   PUBMED   22451516
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF037973.1
            Evidence Source    :: NCBIFAM
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1520
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..1520
                     /gene="sslE"
     Protein         1..1520
                     /product="lipoprotein metalloprotease SslE"
                     /calculated_mol_wt=167116
     Region          106..1511
                     /region_name="SslE_AcfD_Zn_LP"
                     /note="SslE/AcfD family lipoprotein zinc metalloprotease;
                     NF037974"
                     /db_xref="CDD:468296"
ORIGIN      
        1 mnkkfkykks llaailsatl lagcdgggsg sssdtppvds gtgslpevkp dptpnpeptp
       61 eptpdpeptp epipdpeptp epepepvptk tgyltlggsq rvtgatcnge ssdgftfkpg
      121 edvtcvagnt tiatfntqse aarslravek vsfsledaqe lagsddkksn avslvtssns
      181 cpanteqvcl tfssvieskr fdslykqidl apeefkklvn eevennaatd kapsthtspv
      241 vpvttpgtkp dlnasfvsan aeqfyqyqpt eiilsegrlv dsqgygvagv nyytnsgrgv
      301 tgengefsfs wgetisfgid tfelgsvrgn kstialtelg devrganidq lihrysttgq
      361 nntrvvpddv rkvfaeypnv ineiinlsls ngatlgegeq vvnlpnefie qfntgqakei
      421 dtaicaktdg cnearwfslt trnvndgqiq gvinklwgvd tnyksvskfh vfhdstnfyg
      481 stgnargqav vnisnaafpi lmarndknyw lafgekrawd knelayitea pslvepenvt
      541 rdtatfnlpf islgqvgegk lmvignphyn silrcpngys wnggvnkdgq ctlnsdpddm
      601 knfmenvlry lsddkwkpda kasmtvgtnl dtvyfkrhgq vtgnsaafdf hpdfagisve
      661 hlssygdldp qempllilng feyvtqvgnd pyaiplradt skpkltqqdv tdliaylnkg
      721 gsvlimenvm snlkeesasg fvrlldaagl smalnksvvn ndpqgypnrv rqqratgiwv
      781 yerypavdga lpytidsktg evkwkyqven kpddkpklev aswledvdgk qetryafide
      841 adhktedslk aakekifaaf pglkectnpa yhyevncley rpgtgvpvtg gmyvpqytql
      901 slnadtakam vqaadlgtni qrlyqhelyf rtngrkgerl ssvdlerlyq nmsvwlwndt
      961 syryeegknd elgfktftef lncyandaya ggtkcsadlk kslvdnnmiy gdgsskagmm
     1021 npsyplnyme kpltrlmlgr swwdlnikvd vekypgavse egqnvtetis lysnptkwfa
     1081 gnmqstglwa paqkevtiks nanvpvtvtv aladdltgre khevalnrpp rvtktyslda
     1141 sgtvkfkvpy ggliyikgns stnesasftf tgvvkapfyk dgawkndlns paplgelesd
     1201 afvyttpkkn lnasnytggl eqfandldtf assmndfygr dsedgkhrmf tyknlpghkh
     1261 rftndvqisi gdahsgypvm nssfspnstt lpttplndwl iwhevghnaa etpltvpgat
     1321 evannvlaly mqdrylgkmn rvadditvap eyleesnnqa warggagdrl lmyaqlkewa
     1381 eknfdikkwy pdgtplpefy seregmkgwn lfqlmhrkar gdevsndkfg gknycaesng
     1441 naadtlmlca swvaqtdlse ffkkwnpgan ayqlpgasem sfeggvsqsa yntlasldlp
     1501 kpeqgpetin qvtehkmsae