MULTISPECIES: serine protease autotransporter toxin SigA

LOCUS       WP_001034110            1285 aa            linear   BCT 10-JUL-2019
            [Enterobacteriaceae].
ACCESSION   WP_001034110
VERSION     WP_001034110.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 1285)
  AUTHORS   Al-Hasani,K., Henderson,I.R., Sakellaris,H., Rajakumar,K.,
            Grant,T., Nataro,J.P., Robins-Browne,R. and Adler,B.
  TITLE     The sigA gene which is borne on the she pathogenicity island of
            Shigella flexneri 2a encodes an exported cytopathic protease
            involved in intestinal fluid accumulation
  JOURNAL   Infect. Immun. 68 (5), 2457-2463 (2000)
   PUBMED   10768931
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR006073
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1285
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..1285
                     /gene="sigA"
     Protein         1..1285
                     /product="serine protease autotransporter toxin SigA"
                     /calculated_mol_wt=139545
     Region          1..>36
                     /region_name="ESPR"
                     /note="Extended Signal Peptide of Type V secretion system;
                     pfam13018"
                     /db_xref="CDD:463773"
     Region          67..646
                     /region_name="Peptidase_S6"
                     /note="Immunoglobulin A1 protease; pfam02395"
                     /db_xref="CDD:396804"
     Region          757..983
                     /region_name="PL1_Passenger_AT"
                     /note="Pertactin-like passenger domains (virulence
                     factors), C-terminal, subgroup 1, of autotransporter
                     proteins of the type V secretion system of Gram-negative
                     bacteria. This subgroup includes the passenger domains of
                     Neisseria and Haemophilus IgA1 proteases; cd01343"
                     /db_xref="CDD:238653"
     Region          871..1285
                     /region_name="autotrans_barl"
                     /note="outer membrane autotransporter barrel domain;
                     TIGR01414"
                     /db_xref="CDD:273608"
ORIGIN      
        1 mnkiyslkys hitgglvavs eltrkvsvgt srkkvilgii lssiygsyge tafaamldin
       61 niwtrdyldl aqnrgefrpg atnvqlmmkd gkifhfpelp vpdfsavsnk gattsiggay
      121 svtathngtq hhaittqswd qtaykasnrv ssgdfsvhrl nkfvvettgv tesadfslsp
      181 edamkrygvn yngkeqiigf ragagttsti lngkqylfgq nynpdllsas lfnldwknks
      241 yiytnrtpfk nspifgdsgs gsylydkeqq kwvfhgvtst vgfisstnia wtnyslfnni
      301 lvnnlkknft ntmqldgkkq elssiikdkd lsvsgggvlt lkqdtdlgig glifdknqty
      361 kvygkdksyk gagididnnt tvewnvkgva gdnlhkigsg tldvkiaqgn nlkigngtvi
      421 lsaekafnki ymaggkgtvk inakdalses gngeiyftrn ggtldlngyd qsfqkiaatd
      481 agttvtnsnv kqstlsltnt daymyhgnvs gnisinhiin ttqqhnnnan lifdgsvdik
      541 ndisvrnaql tlqghateha ifkegnnncp ipflcqkdys aaikdqestv nkrynteyks
      601 nnqiasfsqp dwesrkfnfr klnlenatls igrdanvkgh ieaknsqivl gnktayidmf
      661 sgrnitgegf gfrqqlrsgd sagessfngs lsaqnskitv gdkstvtmtg alslintdli
      721 inkgatvtaq gkmyvdkaie lagtltltgt ptennkyspa iymsdgynmt edgatlkaqn
      781 yawvngniks dkkasilfgv dqykednldk tthtplatgl lggfdtsytg gidapaasas
      841 myntlwrvng qsalqslktr dslllfsnie nsgfhtvtvn tldatntavi mradlsqsvn
      901 qsdklivknq ltgsnnslsv diqkvgnnns glnvdlitap kgsnkeifka stqaigfsni
      961 spvistkedq ehttwtltgy kvaentassg aaksymsgny kafltevnnl nkrmgdlrdt
     1021 ngeagawari msgagsasgg ysdnythvqi gvdkkheldg ldlftgltmt ytdshassna
     1081 fsgktksvga glyasaifds gayidlisky vhhdneysat faglgtkdys shslyvgaea
     1141 gyryhvteds wiepqaelvy gavsgkrfdw qdrgmsvtmk dkdfnpligr tgvdvgksfs
     1201 gkdwkvtara glgyqfdlfa ngetvlrdas gekrikgekd grilmnvgln aeirdnlrfg
     1261 lefeksafgk ynvdnainan frysf