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LOCUS WP_001031687 487 aa linear BCT 10-JUL-2019 [Salmonella]. ACCESSION WP_001031687 VERSION WP_001031687.1 KEYWORDS RefSeq. SOURCE Salmonella ORGANISM Salmonella Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae. REFERENCE 1 (residues 1 to 487) AUTHORS Kroger,C., Dillon,S.C., Cameron,A.D., Papenfort,K., Sivasankaran,S.K., Hokamp,K., Chao,Y., Sittka,A., Hebrard,M., Handler,K., Colgan,A., Leekitcharoenphon,P., Langridge,G.C., Lohan,A.J., Loftus,B., Lucchini,S., Ussery,D.W., Dorman,C.J., Thomson,N.R., Vogel,J. and Hinton,J.C. TITLE The transcriptional landscape and small RNAs of Salmonella enterica serovar Typhimurium JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (20), E1277-E1286 (2012) PUBMED 22538806 REFERENCE 2 (residues 1 to 487) AUTHORS Luo,Y., Kong,Q., Yang,J., Golden,G., Wanda,S.Y., Jensen,R.V., Ernst,P.B. and Curtiss,R. 3rd. TITLE Complete genome sequence of the universal killer Salmonella enterica Serovar Typhimurium UK-1 (ATCC 68169) JOURNAL J. Bacteriol. 193 (15), 4035-4036 (2011) PUBMED 21622747 REFERENCE 3 (residues 1 to 487) AUTHORS Guarnieri,M.T., Zhang,L., Shen,J. and Zhao,R. TITLE The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ JOURNAL J. Mol. Biol. 379 (1), 82-93 (2008) PUBMED 18440021 REFERENCE 4 (residues 1 to 487) AUTHORS Cho,U.S., Bader,M.W., Amaya,M.F., Daley,M.E., Klevit,R.E., Miller,S.I. and Xu,W. TITLE Metal bridges between the PhoQ sensor domain and the membrane regulate transmembrane signaling JOURNAL J. Mol. Biol. 356 (5), 1193-1206 (2006) PUBMED 16406409 REFERENCE 5 (residues 1 to 487) AUTHORS Sanowar,S. and Le Moual,H. TITLE Functional reconstitution of the Salmonella typhimurium PhoQ histidine kinase sensor in proteoliposomes JOURNAL Biochem. J. 390 (Pt 3), 769-776 (2005) PUBMED 15910283 REFERENCE 6 (residues 1 to 487) AUTHORS Bader,M.W., Sanowar,S., Daley,M.E., Schneider,A.R., Cho,U., Xu,W., Klevit,R.E., Le Moual,H. and Miller,S.I. TITLE Recognition of antimicrobial peptides by a bacterial sensor kinase JOURNAL Cell 122 (3), 461-472 (2005) PUBMED 16096064 REFERENCE 7 (residues 1 to 487) AUTHORS Bijlsma,J.J. and Groisman,E.A. TITLE The PhoP/PhoQ system controls the intramacrophage type three secretion system of Salmonella enterica JOURNAL Mol. Microbiol. 57 (1), 85-96 (2005) PUBMED 15948951 REFERENCE 8 (residues 1 to 487) AUTHORS Tierrez,A. and Garcia-del Portillo,F. TITLE The Salmonella membrane protein IgaA modulates the activity of the RcsC-YojN-RcsB and PhoP-PhoQ regulons JOURNAL J. Bacteriol. 186 (22), 7481-7489 (2004) PUBMED 15516559 REFERENCE 9 (residues 1 to 487) AUTHORS Bader,M.W., Navarre,W.W., Shiau,W., Nikaido,H., Frye,J.G., McClelland,M., Fang,F.C. and Miller,S.I. TITLE Regulation of Salmonella typhimurium virulence gene expression by cationic antimicrobial peptides JOURNAL Mol. Microbiol. 50 (1), 219-230 (2003) PUBMED 14507376 REFERENCE 10 (residues 1 to 487) AUTHORS Sanowar,S., Martel,A. and Moual,H.L. TITLE Mutational analysis of the residue at position 48 in the Salmonella enterica Serovar Typhimurium PhoQ sensor kinase JOURNAL J. Bacteriol. 185 (6), 1935-1941 (2003) PUBMED 12618457 REFERENCE 11 (residues 1 to 487) AUTHORS Chamnongpol,S., Cromie,M. and Groisman,E.A. TITLE Mg2+ sensing by the Mg2+ sensor PhoQ of Salmonella enterica JOURNAL J. Mol. Biol. 325 (4), 795-807 (2003) PUBMED 12507481 REFERENCE 12 (residues 1 to 487) AUTHORS Cano,D.A., Martinez-Moya,M., Pucciarelli,M.G., Groisman,E.A., Casadesus,J. and Garcia-Del Portillo,F. TITLE Salmonella enterica serovar Typhimurium response involved in attenuation of pathogen intracellular proliferation JOURNAL Infect. Immun. 69 (10), 6463-6474 (2001) PUBMED 11553591 REFERENCE 13 (residues 1 to 487) AUTHORS Montagne,M., Martel,A. and Le Moual,H. TITLE Characterization of the catalytic activities of the PhoQ histidine protein kinase of Salmonella enterica serovar Typhimurium JOURNAL J. Bacteriol. 183 (5), 1787-1791 (2001) PUBMED 11160113 REFERENCE 14 (residues 1 to 487) AUTHORS Castelli,M.E., Garcia Vescovi,E. and Soncini,F.C. TITLE The phosphatase activity is the target for Mg2+ regulation of the sensor protein PhoQ in Salmonella JOURNAL J. Biol. Chem. 275 (30), 22948-22954 (2000) PUBMED 10807931 REFERENCE 15 (residues 1 to 487) AUTHORS Kox,L.F., Wosten,M.M. and Groisman,E.A. TITLE A small protein that mediates the activation of a two-component system by another two-component system JOURNAL EMBO J. 19 (8), 1861-1872 (2000) PUBMED 10775270 REFERENCE 16 (residues 1 to 487) AUTHORS van Velkinburgh,J.C. and Gunn,J.S. TITLE PhoP-PhoQ-regulated loci are required for enhanced bile resistance in Salmonella spp JOURNAL Infect. Immun. 67 (4), 1614-1622 (1999) PUBMED 10084994 REFERENCE 17 (residues 1 to 487) AUTHORS Baker,S.J., Gunn,J.S. and Morona,R. TITLE The Salmonella typhi melittin resistance gene pqaB affects intracellular growth in PMA-differentiated U937 cells, polymyxin B resistance and lipopolysaccharide JOURNAL Microbiology (Reading, Engl.) 145 (Pt 2), 367-378 (1999) PUBMED 10075419 REFERENCE 18 (residues 1 to 487) AUTHORS Bearson,B.L., Wilson,L. and Foster,J.W. TITLE A low pH-inducible, PhoPQ-dependent acid tolerance response protects Salmonella typhimurium against inorganic acid stress JOURNAL J. Bacteriol. 180 (9), 2409-2417 (1998) PUBMED 9573193 REMARK Erratum:[J Bacteriol 1998 Jul;180(14):3734] REFERENCE 19 (residues 1 to 487) AUTHORS Vescovi,E.G., Ayala,Y.M., Di Cera,E. and Groisman,E.A. TITLE Characterization of the bacterial sensor protein PhoQ. Evidence for distinct binding sites for Mg2+ and Ca2+ JOURNAL J. Biol. Chem. 272 (3), 1440-1443 (1997) PUBMED 8999810 REFERENCE 20 (residues 1 to 487) AUTHORS Garcia Vescovi,E., Soncini,F.C. and Groisman,E.A. TITLE Mg2+ as an extracellular signal: environmental regulation of Salmonella virulence JOURNAL Cell 84 (1), 165-174 (1996) PUBMED 8548821 REFERENCE 21 (residues 1 to 487) AUTHORS Soncini,F.C., Vescovi,E.G. and Groisman,E.A. TITLE Transcriptional autoregulation of the Salmonella typhimurium phoPQ operon JOURNAL J. Bacteriol. 177 (15), 4364-4371 (1995) PUBMED 7543474 REFERENCE 22 (residues 1 to 487) AUTHORS Behlau,I. and Miller,S.I. TITLE A PhoP-repressed gene promotes Salmonella typhimurium invasion of epithelial cells JOURNAL J. Bacteriol. 175 (14), 4475-4484 (1993) PUBMED 8392513 REFERENCE 23 (residues 1 to 487) AUTHORS Miller,S.I., Kukral,A.M. and Mekalanos,J.J. TITLE A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86 (13), 5054-5058 (1989) PUBMED 2544889 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: BlastRule Evidence Accession :: NBR000715 Evidence Source :: NCBI ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..487 /organism="Salmonella" /db_xref="taxon:590" gene 1..487 /gene="phoQ" Protein 1..487 /product="two-component system sensor histidine kinase PhoQ" /calculated_mol_wt=55336 Region 3..486 /region_name="PRK10815" /note="two-component system sensor histidine kinase PhoQ" /db_xref="CDD:182754" ORIGIN 1 mnkfarhflp lslrvrflla tagvvlvlsl aygivalvgy svsfdkttfr llrgesnlfy 61 tlakwennki svelpenldm qsptmtliyd etgkllwtqr nipwliksiq pewlktngfh 121 eietnvdats tllsedhsaq eklkevredd ddaemthsva vniypatarm pqltivvvdt 181 ipielkrsym vwswfvyvla anlllvipll wiaawwslrp iealarevre ledhhremln 241 pettreltsl vrnlnqllks ererynkyrt tltdlthslk tplavlqstl rslrnekmsv 301 skaepvmleq isrisqqigy ylhrasmrgs gvllsrelhp vaplldnlis alnkvyqrkg 361 vnismdispe isfvgeqndf vevmgnvldn ackyclefve isarqtddhl hifveddgpg 421 iphskrslvf drgqradtlr pgqgvglava reiteqyagq iiasdsllgg armevvfgrq 481 hptqkee