MFS transporter [Escherichia coli].

LOCUS       WP_001000950             454 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_001000950
VERSION     WP_001000950.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 454)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 454)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 454)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 13024624
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     Protein         1..454
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=48592
     Region          17..389
                     /region_name="MFS_YajR_like"
                     /note="Escherichia coli inner membrane transport protein
                     YajR and similar multidrug-efflux transporters of the
                     Major Facilitator Superfamily; cd17472"
                     /db_xref="CDD:341025"
     Site            order(24..25,28..29,32,65,115..116,118..120,123,145,
                     148..149,152,221,224..225,228..230,233,260,264,308..309,
                     313,317,340,343..344,347..348,351)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:341025"
ORIGIN      
        1 mndykmtpge rratwglgtv fslrmlgmfm vlpvlttygm alqgaseali giaigiyglt
       61 qavfqipfgl lsdrigrkpl ivgglavfaa gsviaalsds iwgiilgral qgsgaiaaav
      121 mallsdltre qnrtkamafi gvsfgitfai amvlgpiith klglhalfwm iailattgia
      181 ltiwvvpnss thvlnresgm vkgsfskvla eprllklnfg imclhillms tfvalpgqla
      241 dagfpaaehw kvylatmlia fgsvvpfiiy aevkrkmkqv fvfcvglivv aeivlrnaqt
      301 qfwqlvvgvq lffvafnlme allpsliske spagykgtam gvystsqflg vaiggslggw
      361 idgmfdgqgv flagamlaav wlavastmke ppyvsslrie ipaniaanea lkvrlleteg
      421 ikevliaeee hsayvkidsk vtnrfdveqa irqa