MULTISPECIES: bifunctional indole-3-glycerol-phosphate synthase

LOCUS       WP_000983893             453 aa            linear   BCT 17-NOV-2023
            TrpC/phosphoribosylanthranilate isomerase TrpF [Shigella].
ACCESSION   WP_000983893
VERSION     WP_000983893.1
KEYWORDS    RefSeq.
SOURCE      Shigella
  ORGANISM  Shigella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 453)
  AUTHORS   Eberhard,M. and Kirschner,K.
  TITLE     Modification of a catalytically important residue of
            indoleglycerol-phosphate synthase from Escherichia coli
  JOURNAL   FEBS Lett. 245 (1-2), 219-222 (1989)
   PUBMED   2494074
REFERENCE   2  (residues 1 to 453)
  AUTHORS   Priestle,J.P., Grutter,M.G., White,J.L., Vincent,M.G., Kania,M.,
            Wilson,E., Jardetzky,T.S., Kirschner,K. and Jansonius,J.N.
  TITLE     Three-dimensional structure of the bifunctional enzyme
            N-(5'-phosphoribosyl)anthranilate
            isomerase-indole-3-glycerol-phosphate synthase from Escherichia
            coli
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 84 (16), 5690-5694 (1987)
   PUBMED   3303031
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF006945.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK09427
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Shigella"
                     /db_xref="taxon:620"
     gene            1..453
                     /gene="trpCF"
     Protein         1..453
                     /product="bifunctional indole-3-glycerol-phosphate
                     synthase TrpC/phosphoribosylanthranilate isomerase TrpF"
                     /EC_number="4.1.1.48"
                     /EC_number="5.3.1.24"
                     /GO_function="GO:0004425 - indole-3-glycerol-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0004640 - phosphoribosylanthranilate
                     isomerase activity [Evidence IEA]"
                     /GO_process="GO:0006568 - tryptophan metabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=49379
     Region          1..453
                     /region_name="PRK09427"
                     /note="bifunctional indole-3-glycerol-phosphate synthase
                     TrpC/phosphoribosylanthranilate isomerase TrpF"
                     /db_xref="CDD:236509"
ORIGIN      
        1 mmqtvlakiv adkaiwvetr kqqqplasfq nevqpstrhf ydalqgarta fileckkasp
       61 skgvirddfd pariaaiykh yasaisvltd ekyfqgsfdf llivsqiapq pilckdfiid
      121 pyqiylaryy qadacllmls vldddqyrql aavahslemg vltevsneee leraialgak
      181 vvginnrdlr dlsidlnrtr elapklghnv tvisesgint yaqvrelshf angfligsal
      241 mahddlhaav rrvllgenkv cgltrgqdak aaydagaiyg glifvatspr cvnveqaqev
      301 maaaplqyvg vfrnhdiadv vdkakvlsla avqlhgnedq lyidtlreal pahvaiwkal
      361 svgetlpare fqhvdkyvld ngqggsgqrf dwsllngqsl gnvllagglg adncveaaqt
      421 gcagldfnsa vesqpgikda rllasvfqtl ray