MULTISPECIES: bifunctional indole-3-glycerol-phosphate synthase

LOCUS       WP_000983871             453 aa            linear   BCT 17-MAY-2020
            TrpC/phosphoribosylanthranilate isomerase TrpF
            [Enterobacteriaceae].
ACCESSION   WP_000983871
VERSION     WP_000983871.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 453)
  AUTHORS   Eberhard,M. and Kirschner,K.
  TITLE     Modification of a catalytically important residue of
            indoleglycerol-phosphate synthase from Escherichia coli
  JOURNAL   FEBS Lett. 245 (1-2), 219-222 (1989)
   PUBMED   2494074
REFERENCE   2  (residues 1 to 453)
  AUTHORS   Priestle,J.P., Grutter,M.G., White,J.L., Vincent,M.G., Kania,M.,
            Wilson,E., Jardetzky,T.S., Kirschner,K. and Jansonius,J.N.
  TITLE     Three-dimensional structure of the bifunctional enzyme
            N-(5'-phosphoribosyl)anthranilate
            isomerase-indole-3-glycerol-phosphate synthase from Escherichia
            coli
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 84 (16), 5690-5694 (1987)
   PUBMED   3303031
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF006945.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK09427
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..453
                     /gene="trpCF"
     Protein         1..453
                     /product="bifunctional indole-3-glycerol-phosphate
                     synthase TrpC/phosphoribosylanthranilate isomerase TrpF"
                     /EC_number="4.1.1.48"
                     /EC_number="5.3.1.24"
                     /GO_function="GO:0004425 - indole-3-glycerol-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0004640 - phosphoribosylanthranilate
                     isomerase activity [Evidence IEA]"
                     /GO_process="GO:0006568 - tryptophan metabolic process
                     [Evidence IEA]"
                     /calculated_mol_wt=49361
     Region          1..453
                     /region_name="PRK09427"
                     /note="bifunctional indole-3-glycerol-phosphate synthase
                     TrpC/phosphoribosylanthranilate isomerase TrpF"
                     /db_xref="CDD:236509"
ORIGIN      
        1 mmqtvlakiv adkaiwvear kqqqplasfq nevqpstrhf ydalqgarta fileckkasp
       61 skgvirddfd pariaaiykh yasaisvltd ekyfqgsfnf lpivsqiapq pilckdfiid
      121 pyqiylaryy qadacllmls vldddqyrql aavahslemg vltevsneee qeraialgak
      181 vvginnrdlr dlsidlnrtr elapklghnv tvisesgint yaqvrelshf angfligsal
      241 mahddlhaav rrvllgenkv cgltrgqdak aaydagaiyg glifvatspr cvnveqaqev
      301 maaaplqyvg vfrnhdiadv vdkakvlsla avqlhgneeq lyidtlreal pahvaiwkal
      361 svgetlpare fqhvdkyvld ngqggsgqrf dwsllngqsl gnvllagglg adncveaaqt
      421 gcagldfnsa vesqpgikda rllasvfqtl ray