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LOCUS WP_000973741 329 aa linear BCT 01-MAR-2025 ACCESSION WP_000973741 VERSION WP_000973741.1 KEYWORDS RefSeq. SOURCE Shigella flexneri ORGANISM Shigella flexneri Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Shigella. REFERENCE 1 (residues 1 to 329) AUTHORS Maldonado-Contreras,A., Birtley,J.R., Boll,E., Zhao,Y., Mumy,K.L., Toscano,J., Ayehunie,S., Reinecker,H.C., Stern,L.J. and McCormick,B.A. TITLE Shigella depends on SepA to destabilize the intestinal epithelial integrity via cofilin activation JOURNAL Gut Microbes 8 (6), 544-560 (2017) PUBMED 28598765 REFERENCE 2 (residues 1 to 329) AUTHORS Johnson,T.A., Qiu,J., Plaut,A.G. and Holyoak,T. TITLE Active-site gating regulates substrate selectivity in a chymotrypsin-like serine protease the structure of haemophilus influenzae immunoglobulin A1 protease JOURNAL J Mol Biol 389 (3), 559-574 (2009) PUBMED 19393662 REFERENCE 3 (residues 1 to 329) AUTHORS Henderson,I.R., Czeczulin,J., Eslava,C., Noriega,F. and Nataro,J.P. TITLE Characterization of pic, a secreted protease of Shigella flexneri and enteroaggregative Escherichia coli JOURNAL Infect Immun 67 (11), 5587-5596 (1999) PUBMED 10531204 REFERENCE 4 (residues 1 to 329) AUTHORS Benjelloun-Touimi,Z., Si Tahar,M., Montecucco,C., Sansonetti,P.J. and Parsot,C. TITLE SepA, the 110 kDa protein secreted by Shigella flexneri: two-domain structure and proteolytic activity JOURNAL Microbiology (Reading) 144 (Pt 7), 1815-1822 (1998) PUBMED 9695914 REFERENCE 5 (residues 1 to 329) AUTHORS Stein,M., Kenny,B., Stein,M.A. and Finlay,B.B. TITLE Characterization of EspC, a 110-kilodalton protein secreted by enteropathogenic Escherichia coli which is homologous to members of the immunoglobulin A protease-like family of secreted proteins JOURNAL J Bacteriol 178 (22), 6546-6554 (1996) PUBMED 8932311 REFERENCE 6 (residues 1 to 329) AUTHORS Bachovchin,W.W., Plaut,A.G., Flentke,G.R., Lynch,M. and Kettner,C.A. TITLE Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids JOURNAL J Biol Chem 265 (7), 3738-3743 (1990) PUBMED 2105953 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: HMM Evidence Accession :: NF014452.6 Evidence Source :: EMBL-EBI Source Identifier :: PF02395.22 ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..329 /organism="Shigella flexneri" /db_xref="taxon:623" Protein 1..329 /product="S6 family peptidase" /GO_function="GO:0004252 - serine-type endopeptidase activity [Evidence IEA]" /GO_process="GO:0006508 - proteolysis [Evidence IEA]" /calculated_mol_wt=35982 Region <12..>302 /region_name="Peptidase_S6" /note="Immunoglobulin A1 protease; pfam02395" /db_xref="CDD:396804" ORIGIN 1 mmiykndktf rnleifgdsg sgaylydnkl ekwvlvgtth giasvngdql twitkyndkl 61 vselkdtysh kinlngnnvt ikntditlhq nnadttgtqe kitkdkdivf tnggnvlfkd 121 nldfgsggii fdegheynin gqrftfkgag idigkesivn wnalyssddv lhkigpgtln 181 vqkkqganik igegnvilne egtfnniyla sgngkvilnk dnslgndqya gifftkrggt 241 ldlnghnqtf triaatddgt titnsdtkke avlainneds yiyhgningn iklthninsq 301 dkktnaklil dgsvntkndv evsnasltm