MFS transporter [Escherichia coli].

LOCUS       WP_000956328             421 aa            linear   BCT 01-JAN-2025
ACCESSION   WP_000956328
VERSION     WP_000956328.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 421)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 421)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 421)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10150691
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     Protein         1..421
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=46208
     Region          13..403
                     /region_name="MFS"
                     /note="Major Facilitator Superfamily; cd06174"
                     /db_xref="CDD:349949"
     Site            order(20..21,24..25,28,60,110..111,113,115..116,119,139,
                     142..143,146,228,231..232,235..237,240,268,272,327..328,
                     332,336,353,356..357,360..361,364)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:349949"
ORIGIN      
        1 mltkkkwalf slltlcggti yklpslkdaf yipmqeyfhl tngqignams vnsfvttvgf
       61 flsiyfadkl prrytmsfsl iatgllgvyl ttmpgywgil fvwalfgvtc dmmnwpvllk
      121 svsrlgnseq qgrlfgffet grgivdtvva fsalavftwf gsgllgfkag iwfyslivia
      181 vgitiffvln dkeeapsvev kkedgasqnt smtsvlkdkt iwliafnvff vyavycgltf
      241 fipflkniyl lpvalvgayg iinqyclkmi ggpiggmisd kilkspskyl cytfiistaa
      301 lvllimlphe smpvylgmac tlgfgaivft qravffapig eakiaenktg aamalgsfig
      361 yapamfcfsl ygyildlnpg iigykivfgi macfafcgav vsvmlvkris qrkkemlaae
      421 a