MFS transporter [Shigella flexneri].

LOCUS       WP_000956324             352 aa            linear   BCT 31-DEC-2024
ACCESSION   WP_000956324
VERSION     WP_000956324.1
KEYWORDS    RefSeq.
SOURCE      Shigella flexneri
  ORGANISM  Shigella flexneri
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Shigella.
REFERENCE   1  (residues 1 to 352)
  AUTHORS   Quistgaard,E.M., Low,C., Guettou,F. and Nordlund,P.
  TITLE     Understanding transport by the major facilitator superfamily (MFS):
            structures pave the way
  JOURNAL   Nat Rev Mol Cell Biol 17 (2), 123-132 (2016)
   PUBMED   26758938
REFERENCE   2  (residues 1 to 352)
  AUTHORS   Zhang,X.C., Zhao,Y., Heng,J. and Jiang,D.
  TITLE     Energy coupling mechanisms of MFS transporters
  JOURNAL   Protein Sci 24 (10), 1560-1579 (2015)
   PUBMED   26234418
REFERENCE   3  (residues 1 to 352)
  AUTHORS   Yan,N.
  TITLE     Structural Biology of the Major Facilitator Superfamily
            Transporters
  JOURNAL   Annu Rev Biophys 44, 257-283 (2015)
   PUBMED   26098515
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10150691
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..352
                     /organism="Shigella flexneri"
                     /db_xref="taxon:623"
     Protein         1..352
                     /product="MFS transporter"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport
                     [Evidence IEA]"
                     /calculated_mol_wt=38782
     Region          13..342
                     /region_name="MFS"
                     /note="Major Facilitator Superfamily; cd06174"
                     /db_xref="CDD:349949"
     Site            order(20..21,24..25,28,60,110..111,113,115..116,119,139,
                     142..143,146,228,231..232,235..237,240,268,272,327..328,
                     332,336)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:349949"
ORIGIN      
        1 mltkkkwalf slltlcggti yklpslkdaf yipmqeyfhl tngqignams vnsfvttvgf
       61 flsiyfadkl prrytmsfsl iatgllgvyl ttmpgywgil fvwalfgvtc dmmnwpvllk
      121 svsrlgnseq qgrlfgffet grgivdtvva fsalavftwf gsgllgfkag iwfyslivia
      181 vgiiiffvln dkeeapsvev kkedgasqnt smtsvlrdkt iwliafnvff vyavycgltf
      241 fipflkniyl lpvalvgayg iinqyclkmi ggpiggmisd kilkspskyl cytfiistaa
      301 lvllimlphe smpvylgmac tlgfgaivft qravffapig eakignaanl li