MULTISPECIES: Sir2 family NAD+-dependent deacetylase

LOCUS       WP_000952736             273 aa            linear   BCT 03-OCT-2023
            [Enterobacteriaceae].
ACCESSION   WP_000952736
VERSION     WP_000952736.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
REFERENCE   1  (residues 1 to 273)
  AUTHORS   Mishra,P., Beura,S., Sikder,S., Dhal,A.K., Vasudevan,M., Roy,M.,
            Rakshit,J., Budhwar,R., Kundu,T.K. and Modak,R.
  TITLE     vp1524, a Vibrio parahaemolyticus NAD +-dependent deacetylase,
            regulates host response during infection by induction of host
            histone deacetylation
  JOURNAL   J Biochem 171 (6), 673-693 (2022)
   PUBMED   35325168
REFERENCE   2  (residues 1 to 273)
  AUTHORS   Zhao,K., Chai,X. and Marmorstein,R.
  TITLE     Structure and substrate binding properties of cobB, a Sir2 homolog
            protein deacetylase from Escherichia coli
  JOURNAL   J Mol Biol 337 (3), 731-741 (2004)
   PUBMED   15019790
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF001755.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK00481
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..273
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..273
                     /gene="cobB"
     Protein         1..273
                     /product="Sir2 family NAD+-dependent deacetylase"
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /calculated_mol_wt=30805
     Region          31..271
                     /region_name="PRK00481"
                     /note="NAD-dependent deacetylase; Provisional"
                     /db_xref="CDD:234777"
     Site            order(50,52..53,60..61,110,129..130,132,147,214,219,
                     241..242,257)
                     /site_type="other"
                     /note="NAD+ binding site [chemical binding]"
                     /db_xref="CDD:238703"
     Site            order(131,147,188,190..193,218..220)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:238703"
     Site            order(155,158,174,177)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:238703"
ORIGIN      
        1 mlsrrghrls rfrknkrrlr erlrqriffr dkvvpeamek prvlvltgag isaesgirtf
       61 raadglweeh rvedvatpeg fdrdpelvqa fynarrrqlq qpeiqpnaah lalaklqdal
      121 gdrfllvtqn idnlheragn tnvihmhgel lkvrcsqsgq vldwtgdvtp edkchccqfp
      181 aplrphvvwf gemplgmdei ymalsmadif iaigtsghvy paagfvheak lhgahtveln
      241 lepsqvgnef aekyygpasq vvpefvekll kgl