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LOCUS WP_000904965 146 aa linear BCT 01-JAN-2025 ACCESSION WP_000904965 VERSION WP_000904965.1 KEYWORDS RefSeq. SOURCE Shigella flexneri ORGANISM Shigella flexneri Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Shigella. REFERENCE 1 (residues 1 to 146) AUTHORS Stark,W.M. TITLE The Serine Recombinases JOURNAL Microbiol Spectr 2 (6) (2014) PUBMED 26104451 REFERENCE 2 (residues 1 to 146) AUTHORS Keenholtz,R.A., Rowland,S.J., Boocock,M.R., Stark,W.M. and Rice,P.A. TITLE Structural basis for catalytic activation of a serine recombinase JOURNAL Structure 19 (6), 799-809 (2011) PUBMED 21645851 REFERENCE 3 (residues 1 to 146) AUTHORS Rice,P.A. TITLE Resolving integral questions in site-specific recombination JOURNAL Nat Struct Mol Biol 12 (8), 641-643 (2005) PUBMED 16077726 REFERENCE 4 (residues 1 to 146) AUTHORS Smith,M.C. and Thorpe,H.M. TITLE Diversity in the serine recombinases JOURNAL Mol Microbiol 44 (2), 299-307 (2002) PUBMED 11972771 REFERENCE 5 (residues 1 to 146) AUTHORS Hallet,B. and Sherratt,D.J. TITLE Transposition and site-specific recombination: adapting DNA cut-and-paste mechanisms to a variety of genetic rearrangements JOURNAL FEMS Microbiol Rev 21 (2), 157-178 (1997) PUBMED 9348666 COMMENT REFSEQ: This record represents a single, non-redundant, protein sequence which may be annotated on many different RefSeq genomes from the same, or different, species. ##Evidence-For-Name-Assignment-START## Evidence Category :: Conserved Domain (CDD) Evidence Accession :: Domain architecture ID 10132964 Evidence Source :: NCBI SPARCLE ##Evidence-For-Name-Assignment-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..146 /organism="Shigella flexneri" /db_xref="taxon:623" Protein 1..146 /product="recombinase family protein" /GO_function="GO:0000150 - DNA strand exchange activity [Evidence IEA]" /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_process="GO:0006310 - DNA recombination [Evidence IEA]" /GO_process="GO:0015074 - DNA integration [Evidence IEA]" /calculated_mol_wt=16183 Region 2..126 /region_name="SR_ResInv" /note="Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; cd03768" /db_xref="CDD:239737" Site order(7,9,64..65,68) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:239737" Site 9 /site_type="active" /note="catalytic nucleophile [active]" /db_xref="CDD:239737" Site order(63,107..108,110..111,115) /site_type="other" /note="Presynaptic Site I dimer interface [polypeptide binding]" /db_xref="CDD:239737" Site order(69,74..75,103,106..107,110..111,114,117) /site_type="other" /note="Synaptic Antiparallel dimer interface [polypeptide binding]" /db_xref="CDD:239737" Site order(92..94,103..104,107..108,111,115,118,122) /site_type="other" /note="Synaptic Flat tetramer interface [polypeptide binding]" /db_xref="CDD:239737" Site order(92,108,111,115,118,122) /site_type="other" /note="Synaptic Site I dimer interface [polypeptide binding]" /db_xref="CDD:239737" Site order(116,122..123) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:239737" ORIGIN 1 mligyvrvst ndqntdlqrn alncagceli fedkisgtks erpglkkllk tlsagdtlvv 61 wkldrlgrsm rhlvvlveal rerginfrsl tdsidtstpm grfffhvmga laemereliv 121 ertkagleaa raqgriggrr pklspe