orotidine-5'-phosphate decarboxylase [Escherichia coli].

LOCUS       WP_000881808             265 aa            linear   BCT 10-DEC-2019
ACCESSION   WP_000881808
VERSION     WP_000881808.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 265)
  AUTHORS   Lee,T.S., Chong,L.T., Chodera,J.D. and Kollman,P.A.
  TITLE     An alternative explanation for the catalytic proficiency of
            orotidine 5'-phosphate decarboxylase
  JOURNAL   J. Am. Chem. Soc. 123 (51), 12837-12848 (2001)
   PUBMED   11749542
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF001273.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK00230
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     gene            1..265
                     /gene="pyrF"
     Protein         1..265
                     /product="orotidine-5'-phosphate decarboxylase"
                     /EC_number="4.1.1.23"
                     /GO_function="GO:0004590 - orotidine-5'-phosphate
                     decarboxylase activity [Evidence IEA]"
                     /GO_process="GO:0006207 - 'de novo' pyrimidine nucleobase
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0044205 - 'de novo' UMP biosynthetic
                     process [Evidence IEA]"
                     /calculated_mol_wt=28282
     Region          33..263
                     /region_name="PRK00230"
                     /note="orotidine-5'-phosphate decarboxylase"
                     /db_xref="CDD:234695"
     Site            order(40,42,64,66,91,93,150..151,209,241..242)
                     /site_type="active"
                     /db_xref="CDD:240076"
     Site            order(66,68..69,92..93,95..96,99..100,103..104,119..121,
                     132,150,170,242)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:240076"
ORIGIN      
        1 mlavylfrat sgahhqeglv mtltassssr avtnspvvva ldyhnrdaal afvdkidprd
       61 crlkvgkemf tlfgpqfvre lqqrgfdifl dlkfhdipnt aahavaaaad lgvwmvnvha
      121 sggarmmtaa realvpfgkd aplliavtvl tsmeasdlad lgvtlspady aerlaaltqk
      181 cgldgvvcsa qeavrfkqvf gqefklvtpg irpqgseagd qrrimtpeqa laagvdymvi
      241 grpvtqsvdp aqtlkainas lqrsa