diguanylate cyclase [Escherichia coli].

LOCUS       WP_000878968             315 aa            linear   BCT 20-MAR-2023
ACCESSION   WP_000878968
VERSION     WP_000878968.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Escherichia.
REFERENCE   1  (residues 1 to 315)
  AUTHORS   Pei,J. and Grishin,N.V.
  TITLE     GGDEF domain is homologous to adenylyl cyclase
  JOURNAL   Proteins 42 (2), 210-216 (2001)
   PUBMED   11119645
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 11111091
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..315
                     /organism="Escherichia coli"
                     /db_xref="taxon:562"
     Protein         1..315
                     /product="diguanylate cyclase"
                     /EC_number="2.7.7.65"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0052621 - diguanylate cyclase activity
                     [Evidence IEA]"
                     /calculated_mol_wt=34191
     Region          146..304
                     /region_name="GGDEF"
                     /note="Diguanylate cyclase, GGDEF domain; pfam00990"
                     /db_xref="CDD:425976"
     Site            order(181,224)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:143635"
     Site            order(186,189..190,194,198,220,222..225)
                     /site_type="active"
                     /db_xref="CDD:143635"
     Site            order(216,244)
                     /site_type="active"
                     /note="I-site [active]"
                     /db_xref="CDD:143635"
ORIGIN      
        1 mladwfseqf stgvlivpcm ltlaipgvlp rfkaeqmmpa ialivsvias vviggagsla
       61 fplpaliwca vrytpqvtcl ltfvtgavei vlvansvidi svgspfsipq mfsarlgiat
      121 maicpimvsf svaainslmk qvalradfdf ltqvysrsgl yealkspslk qtqhltvmll
      181 didyfksind nyghecgdkv lsvfarhiqk ivgdkglvar mggeefavav psvnpvdgll
      241 maekirkgve lqpftwqqkt lyltvsigvg sgrasyltlt ddfnklmvea dtclyrskkd
      301 grnrtstmry geevv